机构：[1]Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310051, China.[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai 200336, China.[3]Department of Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai 200336, China.[4]Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, 200092, Shanghai, China.
To systemically examine the concomitant impact of adiposity indices on hypertension in children and adolescents.A community-based cohort study by China Health and Nutrition Survey (2009-2011) included 262 children and adolescents aged 7-17. Anthropometric and lipid profiles were analyzed for hypertension risk using logistic and cross-lagged models.Of the 227 participants (mean age, 16.5 [2.3] years), 147 (53.9%) were boys. Over a two-year period, 26.4% developed hypertension, 5.3% had elevated systolic blood pressure (SBP), and 25.6% had elevated diastolic blood pressure (DBP). After adjusting for covariates, higher body mass index (BMI), waist circumference (WC), hip circumference (HC), triceps skinfold thickness (TST), and body roundness index (BRI) were associated with increased hypertension risk. Incorporating these measures into a BP-based model improved the AUC for hypertension prediction from 0.551 (95% CI: 0.463, 0.640) to 0.670 (95% CI: 0.592, 0.748). A longitudinal relationship were observed between these adiposity indices and hypertension symptoms.The study suggests anthropometry parameters are superior to blood lipid indicators in predicting the occurrence of hypertension in children. Abdominal obesity, as indicated by WC, HC, and BRI, accounts for a significant portion of the risk for hypertension, particularly in children aged 7 to 12 years.
基金：
National Key Research and Development Program of China (grant numbers 2021YFC2701900, 2021YFC2701901, 2021YFC2701903)
语种：
外文
PubmedID：
第一作者：
第一作者机构：[1]Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, 310051, China.[2]Hongqiao International Institute of Medicine, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai 200336, China.[3]Department of Clinical Research Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No.1111, XianXia Road, Shanghai 200336, China.
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推荐引用方式(GB/T 7714)：
Zhu Bowen,Zhan Shumin,Shi Hui,et al.Systematic Evaluation of Adiposity Indices as Predictors of Hypertension Risk in Children and Adolescents[J].Medrxiv : The Preprint Server For Health Sciences.2024,doi:10.1101/2024.11.26.24318031.
APA：
Zhu Bowen,Zhan Shumin,Shi Hui,Wang Xingyun,Yue Jingwen...&Fu Junfen.(2024).Systematic Evaluation of Adiposity Indices as Predictors of Hypertension Risk in Children and Adolescents.Medrxiv : The Preprint Server For Health Sciences,,
MLA：
Zhu Bowen,et al."Systematic Evaluation of Adiposity Indices as Predictors of Hypertension Risk in Children and Adolescents".Medrxiv : The Preprint Server For Health Sciences .(2024)
