Background: Nonobese individuals with disproportionate body fat distribution are also vulnerable to dysglycemia. This study aimed to evaluate the association between three visceral adiposity surrogates and impaired fasting glucose (IFG) in nonobese Chinese individuals. Methods: A total of 70,200 nonobese adults without diabetes were included in this analysis. Two diagnostic criteria (IFG-ADA and IFG-WHO) were used to define IFG. The values of the visceral adiposity index, lipid accumulation product index (LAP), and cardiometabolic index (CMI) were calculated. Multivariable logistic analysis was used to evaluate the association between these surrogates and IFG. Results: Among the three indicators, only LAP and CMI were positively correlated with fasting plasma glucose (all P < 0.001). After fully adjusting for confounders, only LAP and CMI exhibited significant associations with IFG. For women, the odds ratios (ORs) for IFG-ADA in the highest quartile of the LAP and CMI were 1.967 (95% confidence interval [CI]: 1.645-2.353) and 1.594 (95% CI: 1.383-1.836), respectively; and were 2.025 (95% CI: 1.597-2.567) and 2.017 (95% CI: 1.647-2.470), respectively, for IFG-WHO (all P < 0.001). For men, the ORs for IFG-ADA of the LAP and CMI were 1.503 (95% CI: 1.233-1.833) and 2.045 (95% CI: 1.752-2.388), respectively; and were 1.534 (95% CI: 1.174-2.005) and 2.541 (95% CI: 2.025-3.188), respectively, for IFG-WHO (all P < 0.001). Conclusions: The LAP and CMI, cost-effective and simple visceral adiposity surrogates, are strongly associated with IFG in nonobese Chinese individuals. These surrogates might be potential targets to monitor for the recognition and management of excess visceral adiposity in nonobese individuals with prediabetes.
基金：
Shanghai Jiaotong University Curriculum Construction Fund Project [TRJX201907]; Key Project of Shanghai Changning District Natural Science Foundation [CNKW2016Z03]
第一作者机构：[1]Soochow Univ, Dept Endocrinol, Affiliated Hosp 3, 185 Bur St, Changzhou 213000, Jiangsu, Peoples R China[2]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Endocrinol, Shanghai, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Soochow Univ, Dept Endocrinol, Affiliated Hosp 3, 185 Bur St, Changzhou 213000, Jiangsu, Peoples R China[3]Chinese Air Force, Hangzhou Aeronaut Sanat, 27 Yang Gong Di, Hangzhou 310007, Zhejiang, Peoples R China[*1]Hangzhou Aeronautical Sanatorium of Chinese Air Force No. 27, Yang Gong Di, Xihu District Hangzhou 310007 Zhejiang China[*2]Department of Endocrinology The Third Affiliated Hospital of Soochow University No. 185, Bureau Street, Tianning District Changzhou 213000 Jiangsu China
推荐引用方式(GB/T 7714)：
Li Hui Hua,Wang Jun Min,Ji Yi Xin,et al.Association of Visceral Adiposity Surrogates with Impaired Fasting Glucose in Nonobese Individuals[J].METABOLIC SYNDROME AND RELATED DISORDERS.2020,18(3):128-133.doi:10.1089/met.2019.0078.
APA：
Li, Hui Hua,Wang, Jun Min,Ji, Yi Xin,Lin, Lin,Li, Shu Wen...&Liu, Xing Zhen.(2020).Association of Visceral Adiposity Surrogates with Impaired Fasting Glucose in Nonobese Individuals.METABOLIC SYNDROME AND RELATED DISORDERS,18,(3)
MLA：
Li, Hui Hua,et al."Association of Visceral Adiposity Surrogates with Impaired Fasting Glucose in Nonobese Individuals".METABOLIC SYNDROME AND RELATED DISORDERS 18..3(2020):128-133
