机构：[1]Chinese Univ Hong Kong, Shantou Univ, Joint Shantou Int Eye Ctr, North Dongxia Rd, Shantou 515041, Peoples R China[2]Southeast Univ, Nanjing Tongren Hosp, Sch Med, Nanjing, Peoples R China[3]Chinese Univ Hong Kong, Dept Ophthalmol & Visual Sci, Hong Kong, Peoples R China
PurposeTo evaluate changes in intraocular pressure (IOP) in dominant and contralateral eyes following the dark room prone provocative test (DRPPT) in the study subjects with shallow anterior chamber. MethodsThis was a prospective, single-center, non-randomized controlled trial of 43 subjects (86 eyes) with shallow anterior chamber. The dominant eye was identified using the card-hole method. The study subjects underwent the DRPPT for one hour. Pre- and post-DRPPT IOP was measured using an I-Care tonometer, and pupillary parameters, including amplitude of constriction, peak constriction velocity, and peak re-dilation velocity, were also measured using the RAPDx (R) dynamic pupillometer. ResultsSignificant increases in IOP were observed in both the dominant and contralateral eyes after DRPPT, compared to their respective pre-DRPPT IOP levels. (p < .01). Moreover, IOP variation before and after DRPPT was significantly greater in the dominant eye than in the contralateral eye (median 3.60 mmHg vs. 2.70 mmHg, p < .05). The dominant eyes exhibited a smaller amplitude of constriction (1.07 +/- 0.35 mm vs 1.14 +/- 0.34 mm, P < .05) and slower constriction velocity (3.71 +/- 1.12 mm/s vs 3.78 +/- 1.11 mm/s, P < .05) as compared to the contralateral eyes. ConclusionsThis study demonstrated that the dominant eye exhibited greater IOP changes after DRPPT than the contralateral eye. Additionally, it showed smaller pupil constriction and slower contraction, indicating a higher likelihood of pupil blockage in the dominant eye with shallow anterior chambers. This asymmetry partially explains the monocular onset of acute angle-closure attacks.
基金：
Intramural Research Assistance Foundation of Joint Shantou International Eye Center (JSIEC) of The Shantou University [19-022]; Chinese University of Hong Kong
第一作者机构：[1]Chinese Univ Hong Kong, Shantou Univ, Joint Shantou Int Eye Ctr, North Dongxia Rd, Shantou 515041, Peoples R China
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推荐引用方式(GB/T 7714)：
Wang Junwei,Wang Jun,Ng Tsz Kin,et al.Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test[J].SEMINARS IN OPHTHALMOLOGY.2025,doi:10.1080/08820538.2024.2443972.
APA：
Wang, Junwei,Wang, Jun,Ng, Tsz Kin&Huang, Chukai.(2025).Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test.SEMINARS IN OPHTHALMOLOGY,,
MLA：
Wang, Junwei,et al."Asymmetric Intraocular Pressure Changes in Dominant and Contralateral Eyes: The Dark Room Prone Provocative Test".SEMINARS IN OPHTHALMOLOGY .(2025)
