Background: Acute pancreatitis (AP) ranks among the most frequently encountered gastrointestinal diseases in the emergency department. Recent studies have increasingly emphasized the substantial connection among gut microbiota, inflammatory cytokines, and AP. Methods: A two-sample Mendelian randomization (MR) study was conducted using summary statistics of gut microbiota (GM) from the largest available meta-analysis of genome-wide association studies conducted by the MiBioGen consortium ( n = 18,340). For cytokines, the data were obtained from a study that investigated genome variant associations with 41 inflammatory cytokines and growth factors ( n = 8293). The summary statistics of AP were obtained from the FinnGen consortium version R5 data (3022 cases and 195,144 controls). The inverse variance weighted (IVW) method was used as the main analysis, with MR-Egger and weighted median as complementary analytical methods. Sensitivity analyses were performed using Cochran's Q-test, MR-Egger intercept test, leave-one-out analyses, and MR-PRESSO. In addition, we employed the reverse MR analysis and MR Steiger method to estimate the orientations of exposure and outcome. Result: Among the 211 examined GM taxa, the IVW method revealed that Bacteroidales (odds ratio [OR] = 1.412, 95% confidence interval [CI]:1.057 to 1.885, P = 0.019), Eubacterium fissicatena group (OR = 1.240, 95% CI:1.045 to 1.470, P = 0.014), and Coprococcus3 (OR = 1.481, 95 % CI:1.049 to 2.090, P = 0.026) exhibited a positive association with AP. Conversely, Prevotella9 (OR = 0.821, 95% CI:0.680 to 0.990, P = 0.038), RuminococcaceaeUCG004 (OR = 0.757, 95% CI:0.577 to 0.994, P = 0.045), and Ruminiclostridium6 (OR = 0.696, 95% CI:0.548 to 0.884, P = 0.003) displayed a negative correlation with AP. Among the 41 inflammatory cytokines, only macrophage colony-stimulating factor (M_CSF, OR = 0.894, 95% CI:0.847 to 0.943, P = 0.037) exhibited a negative association with AP. Sensitivity analyses revealed no evidence of pleiotropy or heterogeneity. Nevertheless, the mediation analysis showed that M_CSF did not act as a mediating factor. Conclusion: This two-sample MR study revealed causal associations between specific GM and inflammatory cytokines with AP, respectively. However, inflammatory cytokines did not appear to act as mediating factors in the pathway from GM to AP.
基金：
Scientific research project of Health and Wellness Committee Changning District Shanghai [20214Y007]; Research Fund of Shanghai TongrenHospital, Shanghai Jiaotong University School of Medicine [TRYJ2021LC02]
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外文
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出版当年[2025]版：
大类|4 区医学
小类|4 区危重病医学
最新[2025]版：
大类|4 区医学
小类|4 区危重病医学
第一作者：
第一作者机构：[1]Air Force Med Univ, Tangdu Hosp, Dept Crit Care Med, Xian 710038, Shaanxi, Peoples R China[2]Shanghai Jiao Tong Univ, Tongren Hosp, Digest Endoscopy Ctr, Sch Med, Shanghai, Peoples R China
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推荐引用方式(GB/T 7714)：
Wang Xiaofeng,Qiu Yiwen,Di Ying,et al.Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study[J].JOURNAL OF INTENSIVE MEDICINE.2025,5(2):185-192.doi:10.1016/j.jointm.2024.10.004.
APA：
Wang, Xiaofeng,Qiu, Yiwen,Di, Ying,Hou, Shaohua,Wu, Wei...&Li, Pu.(2025).Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study.JOURNAL OF INTENSIVE MEDICINE,5,(2)
MLA：
Wang, Xiaofeng,et al."Potential causal association between gut microbiota, inflammatory cytokines, and acute pancreatitis: A Mendelian randomization study".JOURNAL OF INTENSIVE MEDICINE 5..2(2025):185-192
