Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitis
机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China 临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China 临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China 研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Laboratory for Clinical Medicine, Capital Medical University, Beijing, China
Seasonal allergic rhinitis (SAR) caused by pollen exposure is a
serious worldwide health issue [1]. In grasslands of northern
China, SAR prevalence reaches 32.4% due to high seasonal
pollen concentrations, primarily from Artemisia, Chenopodium,
and Humulus, with Artemisia being the most potent sensitizing
species [2]. While previous cross-sectional studies demonstrated
the link between daily pollen levels and clinic visits [3], they
inadequately captured the impact of pollen exposure on temporal
changes in symptoms. A controlled study found that reduced
pollen exposure during peak pollen periods correlated with
symptom improvement and decreased nasal total immunoglobulin E (IgE) [4]. Furthermore, a panel study revealed that SAR
patients exhibited elevated nasal-specific IgE (sIgE) compared
with controls only in pollen season, with no serum differences
observed [5].
基金：
the national key R&D program of China (2022YFC2504100), the program for the Changjiang scholars and innovative research team (IRT13082), Natural Science Foundation of China (82471132, 82271141 and 8180886), Beijing Municipal Science & Technology
Commission (Z211100002921060), and Beijing Hospitals Authority Clinical Medicine Development of special funding (ZLRK202303).
第一作者机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China [3]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
通讯作者：
通讯机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China [3]Beijing Laboratory of Allergic Diseases and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China [4]Laboratory for Clinical Medicine, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Liu Dong,Zhang Yuan,Li Jingyun,et al.Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitis[J].INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY.2025,doi:10.1002/alr.23621.
APA：
Liu, Dong,Zhang, Yuan,Li, Jingyun,Zhang, Xu,Zhang, Luo&Wang, Chengshuo.(2025).Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitis.INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY,,
MLA：
Liu, Dong,et al."Nasal-Specific Immunoglobulin E to Total Immunoglobulin E Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitisto Total IgE Ratio Mediates the Effect of Natural Pollen Exposure on Symptom Severity in Patients with Seasonal Allergic Rhinitis".INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY .(2025)
