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A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome

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机构: [1]Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing 100020, China [2]Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing, China [3] Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Logistics College of Chinese Armed Police Forces, Tianjin, China [4]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China [5] Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China [6] The Pulmonary Department, Fujian Province Hospital, Fuzhou, Fujian Province, China [7] Department of Respiratory and Critical Care Medicine, The Third Affiliated Hospital of Inner Mongolia Medical College, Baotou, Inner Mongolia Autonomous Region, China [8]The Pulmonary Department, Xijing Hospital of the Fourth Military Medical University, Xi’an, Shanxi Province, China [9]The Pulmonary Department, The Third People’s Hospital of Chengdu, Chengdu, Sichuan Province, China [10]Department of Critical Care Medicine, Chengdu Fifth People’s Hospital, Chengdu, Sichuan Province, China [11]Department of Respiratory Medicine, People’s Hospital of Beijing Daxing District, Beijing, China [12]Department of Pulmonary and Critical Care Medicine, Chinese PLA General Hospital, Beijing, China [13]Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shanxi Province, China [14]The Pulmonary Department, Lung Disease Hospital of Fujian Fuzhou, Fuzhou, Fujian Province, China [15]The Pulmonary Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China [16]The Pulmonary Department, Beijing Tongren Hospital, Beijing, China. [17]Department of Respiratory and Critical Care Medicine, Tangdu Hospital, the Fourth Military Medical University, Xi’an, Shanxi Province, China [18]The Pulmonary Department, Peking University Third Hospital, Beijing, China. [19]The Pulmonary Department, Xinqiao Hospital Army Medical University, Chongqing, China [20]Department of Respiratory and Critical Care Medicine, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang Uygur Autonomous Region, China [21]Department of Respiratory and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Province, China [22]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [23]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No.2 Yinghua East Road, Chaoyang District, Beijing 100029, China [24]Department of Respiratory Medicine, Capital Medical University, Beijing, China [25]National Clinical Research Center for Respiratory Diseases, Beijing, China.
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关键词: Acute respiratory distress syndrome (ARDS) Noninvasive ventilation (NIV) Pneumonia

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Rationale: Our pilot study suggested that noninvasive ventilation (NIV) reduced the need for intubation compared with conventional administration of oxygen on patients with "early" stage of mild acute respiratory distress syndrome (ARDS, PaO2/FIO2 between 200 and 300). Objectives: To evaluate whether early NIV can reduce the need for invasive ventilation in patients with pneumonia-induced early mild ARDS. Methods: Prospective, multicenter, randomized controlled trial (RCT) of NIV compared with conventional administration of oxygen through a Venturi mask. Primary outcome included the numbers of patients who met the intubation criteria. Results: Two hundred subjects were randomized to NIV (n = 102) or control (n = 98) groups from 21 centers. Baseline characteristics were similar in the two groups. In the NIV group, PaO2/FIO2 became significantly higher than in the control group at 2 h after randomization and remained stable for the first 72 h. NIV did not decrease the proportion of patients requiring intubation than in the control group (11/102 vs. 9/98, 10.8% vs. 9.2%, p = 0.706). The ICU mortality was similar in the two groups (7/102 vs. 7/98, 4.9% vs. 3.1%, p = 0.721). Multivariate analysis showed minute ventilation greater than 11 L/min at 48 h was the independent risk factor for NIV failure (OR, 1.176 [95% CI, 1.005-1.379], p = 0.043). Conclusions: Treatment with NIV did not reduce the need for intubation among patients with pneumonia-induced early mild ARDS, despite the improved PaO2/FIO2 observed with NIV compared with standard oxygen therapy. High minute ventilation may predict NIV failure. Trial registration: NCT01581229. Registered 19 April 2012 © 2019 The Author(s).

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出版当年[2018]版:
大类 | 2 区 医学
小类 | 3 区 危重病医学
最新[2023]版:
大类 | 1 区 医学
小类 | 2 区 危重病医学
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Q1 CRITICAL CARE MEDICINE
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Q1 CRITICAL CARE MEDICINE

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第一作者机构: [1]Department of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine, Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Engineering Research Center for Diagnosis and Treatment of Pulmonary and Critical Care, Beijing Chao-Yang Hospital, Capital Medical University, No.8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing 100020, China
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通讯机构: [22]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China [23]Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, No.2 Yinghua East Road, Chaoyang District, Beijing 100029, China [24]Department of Respiratory Medicine, Capital Medical University, Beijing, China [25]National Clinical Research Center for Respiratory Diseases, Beijing, China.
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