机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
Objective: Diabetes mellitus (DM) and diabetic retinopathy (DR) are associated with oxidative stress and carotenoids have antioxidant properties. This study aimed to test the relationship between serum carotenoid concentrations and the risk for DM and DR. Methods: This is a cross-sectional study of the Chinese urban population. A total of 747 subjects, consisting of 272 DR patients, 190 diabetic patients without retinopathy, and 285 non-diabetes mellitus healthy controls, were recruited to this study. Demographic and lifestyle characteristics were ascertained by questionnaire. General physical and ophthalmic examinations were completed for all participants. Serum carotenoids were measured by high-performance liquid chromatography (HPLC). The associations of serum carotenoids with DM and DR were assessed by logistic regression with adjustment of known risk factors. The correlation analyses of serum carotenoids with the candidate influence factors were assessed using the single variable linear regression. Results: Both pro-vitamin A (PVA) carotenoids and non-PVA carotenoids in the serum were measured and compared between different groups. Levels of a-carotene were significantly lower in DR patients and beta-carotene were significantly lower in DM patients as compared to non DM healthy control group. In contrast, levels of beta-cryptoxanthin, lycopene, lutein and zeaxanthin were comparable among different groups. After adjusting for confounding factors, beta-carotene concentration was associated with reduced risk for DM (OR (95% CI): 0.56 (0.34, 0.91), P=0.02) and a-carotene was associated with reduced risk for DR in non-smokers (OR (95% CI): 0.41 (0.17, 0.99), P=0.048). No significant association was found between hemoglobin A1c and any carotenoids (P>0.05). Significantly associations with serum carotenoids were found in age, sex, BMI, smoking, and exercise (P<0.05). Conclusion: Serum beta-carotene may have a protective effect on DM and a-carotene may be a protective factor for DR in non-smokers.
第一作者机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
通讯作者:
通讯机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No. 1 Dong Jiao Min Xiang, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714):
She C.,Shang F.,Zhou K.,et al.Serum Carotenoids and Risks of Diabetes and Diabetic Retinopathy in a Chinese Population Sample[J].CURRENT MOLECULAR MEDICINE.2017,17(4):287-297.doi:10.2174/1566524017666171106112131.
APA:
She, C.,Shang, F.,Zhou, K.&Liu, N..(2017).Serum Carotenoids and Risks of Diabetes and Diabetic Retinopathy in a Chinese Population Sample.CURRENT MOLECULAR MEDICINE,17,(4)
MLA:
She, C.,et al."Serum Carotenoids and Risks of Diabetes and Diabetic Retinopathy in a Chinese Population Sample".CURRENT MOLECULAR MEDICINE 17..4(2017):287-297