北京市医院管理局"登峰"人才培养计划;科技创新基地培育与发展专项项 目;国家自然科学基金;北京市科技计划项目(Z181100001818003)Beijing Municipal Administration of Hospitals' Ascent Plan;Science& Technology Project of Bering Municipal Science&Technology Commission;Nation-al Natural Science Foundation of China;Beijing Municipal Science and Tehcnology Project