机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing 100005, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China
Objective: To investigate factors that contribute to lymph node metastasis (LNM) from clinical cT2-T4 N0M0 (cN0) supraglottic laryngeal carcinoma (SLC), and to predict the risk of occult metastasis before surgery. Methods: A total of 121 patients who received surgery were retrospectively analyzed. Relevant factors regarding cervical LNM were analyzed. Multivariate analyses were conducted to predict the region where the metastasis occurred and prognosis. Results: The overall metastatic rate of cN0 SLC was 28.1%. Metastatic rates were 15.4%, 32.5% and 35.7% for T2, T3 and T4, respectively. Metastatic rates for SLC levels II, Ill and IV were 19.6%, 17.2% and 3.6%, respectively. A regression equation was formulated to predict the probability of metastasis in cN0 SLC as follows: Pn=e((-3.874+0.749T3+1.154T4+1 935P1+1.750P2))/[1+e((-3.874+0.749T3+1 154T4+1.935P1+1.750P2))]. Approximately 0.2% of patients experienced LNM with no recurrence of laryngeal cancer. Comparison of the intergroup survival curves between patients with and without LNM indicated a statistically significant difference (P=0.029). Conclusions: Cervical lymph node metastatic rates tended to increase in tandem with T stage in patients with LNM in cN0 SLC, and neck dissection is advised for these patients. Moreover, cervical LNM in cN0 SLC showed a sequential pattern and may be predicted.
基金：
This work was supported by “Beijing City, the
hospital authority clinical technology innovation project
(Grant No. XMLX201311)”, “The Beijing Municipal
Science and Technology Commission capital characteristic
cl inical appl ication research project (Grant No.
Z141107002514003)” and “Special Research Found for the Doctoral Program of Higher Education (Grant No.
20121107110021)”.
第一作者机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[2]Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing 100005, China
通讯作者：
通讯机构：[1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[2]Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Institute of Otorhinolaryngology, Beijing 100005, China[3]Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology, Beijing 100730, China[*1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Ma Hongzhi,Lian Meng,Feng Ling,et al.Factors contributing to lymph node occult metastasis in supraglottic laryngeal carcinoma cT2-T4 N0M0 and metastasis predictive equation[J].CHINESE JOURNAL OF CANCER RESEARCH.2014,26(6):685-691.doi:10.3978/j.issn.1000-9604.2014.12.06.
APA：
Ma, Hongzhi,Lian, Meng,Feng, Ling,Li, Pingdong,Hou, Lizhen...&Fang, Jugao.(2014).Factors contributing to lymph node occult metastasis in supraglottic laryngeal carcinoma cT2-T4 N0M0 and metastasis predictive equation.CHINESE JOURNAL OF CANCER RESEARCH,26,(6)
MLA：
Ma, Hongzhi,et al."Factors contributing to lymph node occult metastasis in supraglottic laryngeal carcinoma cT2-T4 N0M0 and metastasis predictive equation".CHINESE JOURNAL OF CANCER RESEARCH 26..6(2014):685-691
