Normal tension glaucoma (NTG) is a neurodegenerative disease involves multiple brain areas, but the mechanism remains unclear. The aim of this study is to investigate the correlation between structural injury and functional reorganization in the brain of NTG, using resting-state functional MRI and diffusion kurtosis imaging (DKI) data acquired for 26 NTG patients and 24 control subjects. Granger causality analysis (GCA) was used to calculate the effective connectivity (EC) between visual cortices and the whole brain to reflect the information flow. The fractional anisotropy (FA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK) derived from DKI of visual cortices were extracted to evaluate structural injury. Microstructural abnormalities were detected in bilateral BA17, BA18, and BA19. NTG patients showed significantly decreased EC from BA17 to higher visual cortices and increase EC from higher visual cortices to BA17. The EC from BA17 to posterior cingulate cortex (PCC) and from PCC to BA17 both significantly increased, while the EC from right BA18 and BA19 to PCC significantly decreased. Decreased EC between somatosensory cortex and BA17, as well as the decreased ECs between supramarginal gyrus (SMA) and BA17/BA19 were detected. Several abnormal ECs were significantly correlated with microstructural injuries of BA17 and BA18. In conclusion, NTG causes reorganization of information flows among visual cortices and other brain areas, which is consistent with brain microstructural injury.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81701666, 81871340, 81901719, 81571649]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support, China [ZYLX201704]; Beijing Municipal Administration of Hospitals' Ascent Plan, China [DFL20190203]; Capital Health Development Special Fund of China -Youth Project [2018-4-1083]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing, Peoples R China
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推荐引用方式(GB/T 7714)：
Li Ting,Qu Xiaoxia,Chen Weiwei,et al.Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI[J].BRAIN RESEARCH.2020,1741:doi:10.1016/j.brainres.2020.146874.
APA：
Li, Ting,Qu, Xiaoxia,Chen, Weiwei,Wang, Qian,Wang, Huaizhou...&Xian, Junfang.(2020).Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI.BRAIN RESEARCH,1741,
MLA：
Li, Ting,et al."Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma: Evidence from resting-state fMRI and DKI".BRAIN RESEARCH 1741.(2020)
