机构：[1]Department of Radiology, Beijing Tongren Hospital, CapitalMedical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China首都医科大学附属北京同仁医院医技科室放射科[2]Clinical Center for Eye Tumors, Capital Medical University, Beijing, China
Purpose To evaluate the diagnostic performance of the quantitative parameters derived from diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) MRI in differentiating lacrimal gland pleomorphic adenomas (LGPAs) from lacrimal gland malignant epithelial tumors (LGMETs). Methods Seventy-seven cases with LG epithelial tumors confirmed by histopathology (47 LGPAs and 30 LGMETs) underwent DWI and DCE-MRI. The quantitative parameters including the apparent diffusion coefficient (ADC), the volume transfer constant (K-trans), the efflux rate constant from the extravascular extracellular space (EES) to blood plasma (K-ep), and the extravascular extracellular volume fraction (V-e) were used to differentiate LGPAs from LGMETs. Independent-samples t test was conducted to compare these parameters. The diagnostic performance was evaluated using receiver operating characteristic (ROC) curve analysis. Results Compared with LGPAs, LGMETs had significantly lower ADC value (1.090 +/- 0.169mm(2)/s) (P < 0.001), higher K-trans value (0.892 +/- 0.517/min) (P = 0.001), and K-ep value (1.300 +/- 1.131/min) (P = 0.002). ADC as a diagnostic index showed a better diagnostic efficacy in predicting malignant tumors (AUC 0.914, sensitivity 90.0%, specificity 85.1%, and accuracy 87.0%) than K-trans and K-ep alone. The combination of ADC and K-trans presented the optimal diagnostic performance for the differentiation (AUC 0.938, sensitivity 93.3%, specificity 87.2%, accuracy 89.6%). Conclusion The quantitative parameters including ADC, K-trans, and K-ep derived from DWI and DCE-MRI might be potential imaging biomarkers in differentiating LGPAs from LGMETs. The combination of ADC and K-trans is superior to other quantitative parameters in distinguishing LGPAs from LGMETs.
基金：
Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20190203]; Beijing Municipal Administration of Hospitals' Clinical Medicine Development of Special Funding Support [ZYLX201704]; High Level Health Technical Personnel of Bureau of Health in Beijing [2014-2-005]
语种：
外文
高被引：
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2019]版：
大类|3 区医学
小类|3 区核医学4 区临床神经病学4 区神经成像
最新[2023]版：
大类|3 区医学
小类|3 区临床神经病学3 区神经成像3 区核医学
JCR分区：
出版当年[2018]版：
Q2NEUROIMAGINGQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ3CLINICAL NEUROLOGY
最新[2023]版：
Q2CLINICAL NEUROLOGYQ2RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ2NEUROIMAGING
第一作者机构：[1]Department of Radiology, Beijing Tongren Hospital, CapitalMedical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China[2]Clinical Center for Eye Tumors, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Radiology, Beijing Tongren Hospital, CapitalMedical University, No. 1, Dongjiaominxiang, Dongcheng District, Beijing 100730, China[2]Clinical Center for Eye Tumors, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Yongzhe,Song Liyuan,Guo Jian,et al.Value of quantitative multiparametric MRI in differentiating pleomorphic adenomas from malignant epithelial tumors in lacrimal gland[J].NEURORADIOLOGY.2020,62(9):1141-1147.doi:10.1007/s00234-020-02455-3.
APA：
Wang, Yongzhe,Song, Liyuan,Guo, Jian&Xian, Junfang.(2020).Value of quantitative multiparametric MRI in differentiating pleomorphic adenomas from malignant epithelial tumors in lacrimal gland.NEURORADIOLOGY,62,(9)
MLA：
Wang, Yongzhe,et al."Value of quantitative multiparametric MRI in differentiating pleomorphic adenomas from malignant epithelial tumors in lacrimal gland".NEURORADIOLOGY 62..9(2020):1141-1147
