Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year
机构:[1]Department of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China[2]Department of Neurology, Shanghai TongRen Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China[3]Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, Shanghai, China
Objective To evaluate the cognitive function of Chinese patients with Parkinson's disease PD postsubthalamic nucleus deep brain stimulation (STN-DBS). Methods Cognitive function was assessed by neuropsychological methods in PD patients. Twenty matched healthy persons served as normal controls. t test, analysis of variance, and chi-square analysis were used to compare the difference among the groups. Reliable change index was utilized to analyze the changes in cognition from the individual level. Results (a) Improvement in motor function was significantly better after STN-DBS (P < .01). (b) Notably, the increase error rates of implicit SRTT (serial reaction time task) was significantly higher after STN-DBS as compared with the conservative therapy group (P = .03). (c) The decline of verbal fluency (explicit) was also significantly higher after STN-DBS than that in the medication therapy group (P = .03). (d) In the explicit clock-drawing test, scores had significantly improved after STN-DBS (P = .04). Conclusions STN-DBS as a neuromodulatory tool in the Chinese PD population not only improves motor symptoms but also cognitive function to a certain extent, such as the decline of executive function and verbal fluency. The explicit cognitive decline was significantly quicker than that in patients on medication therapy. The improvement of visiospatial function was also noted. Implicit memory impairment during the 1-year follow-up period was not observed.
基金:
This paper is supported by National Natural
Foundation of China (81071065# and
81671103#).
第一作者机构:[1]Department of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China[2]Department of Neurology, Shanghai TongRen Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Neurology, Shanghai General Hospital of Nanjing Medical University, Shanghai, China[2]Department of Neurology, Shanghai TongRen Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China[3]Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, Shanghai, China[*1]Department of Neurology, Shanghai Jiao-Tong University School of Medicine, Shanghai 200336, China.[*2]Department of Neurosurgery, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China.
推荐引用方式(GB/T 7714):
You ZhiFei,Wu Yi- Ying,Wu Rong,et al.Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year[J].CNS NEUROSCIENCE & THERAPEUTICS.2020,26(9):972-980.doi:10.1111/cns.13392.
APA:
You, ZhiFei,Wu, Yi- Ying,Wu, Rong,Xu, Zhi-Xiang,Wu, Xi&Wang, Xiao-Ping.(2020).Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year.CNS NEUROSCIENCE & THERAPEUTICS,26,(9)
MLA:
You, ZhiFei,et al."Efforts of subthalamic nucleus deep brain stimulation on cognitive spectrum: From explicit to implicit changes in the patients with Parkinson's disease for 1 year".CNS NEUROSCIENCE & THERAPEUTICS 26..9(2020):972-980