机构：[1]Department of Interventional Radiology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China[2]State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Aberrant expression of the tripartite motif containing 59 (TRIM59) has been reported to participate in the development and progression of various human cancers. However, its expression pattern and cellular roles in pancreatic cancer (PC) remains unclear. In our study, we found that TRIM59 expression was significantly increased in PC tissues and was positively correlated with several malignant behaviors and poor overall survival of PC patients based on bioinformatics analysis and immunohistochemistry staining. Functionally, small interfering RNA-mediated TRIM59 depletion inhibited cell proliferation and migration in vitro, while TRIM59 overexpression promoted cell proliferation and migration in vitro and drove tumor growth and liver metastasis in vivo. Mechanically, TRIM59 was found to enhance glycolysis through activating the PI3K/AKT/mTOR pathway, ultimately contributing to PC progression. Taken together, our results demonstrate that TRIM59 may be a potential predictor for PC and promotes PC progression via the PI3K/AKT/mTOR-glycolysis signaling pathway, which establishes the rationale for targeting the TRIM59-related pathways to treat PC.
基金：
Shanghai Science and Technology
Program, Grant/Award Number:
16411952600
第一作者机构：[1]Department of Interventional Radiology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Interventional Radiology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China[2]State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China[*1]State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, 800 Dongchuan Road, 200240 Shanghai, China.[*2]Department of Interventional Radiology, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, 1111 Xianxia Road, 200336 Shanghai, China.
推荐引用方式(GB/T 7714)：
Li Rongkun,Weng Li,Liu Bingyan,et al.TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR-glycolysis signaling axis[J].JOURNAL OF CELLULAR BIOCHEMISTRY.2020,121(2):1986-1997.doi:10.1002/jcb.29433.
APA：
Li, Rongkun,Weng, Li,Liu, Bingyan,Zhu, Lili,Zhang, Xiaoxin...&Shang, Mingyi.(2020).TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR-glycolysis signaling axis.JOURNAL OF CELLULAR BIOCHEMISTRY,121,(2)
MLA：
Li, Rongkun,et al."TRIM59 predicts poor prognosis and promotes pancreatic cancer progression via the PI3K/AKT/mTOR-glycolysis signaling axis".JOURNAL OF CELLULAR BIOCHEMISTRY 121..2(2020):1986-1997
