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Stability of regulatory T cells in T helper 2-biased allergic airway diseases

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收录情况： ◇ SCIE

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机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Nasal Disease, Beijing Institute of Otolaryngology, Beijing, China [3]Upper Airways Research Laboratory, ENT Department, Ghent University, Ghent, Belgium

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关键词： airway disease peripherally derived regulatory T cell T helper 2 thymus-derived regulatory T cell

摘要：

Regulatory T (Treg) cells potentially suppress the deleterious activities of effector T cells and maintain a state of tolerance against antigens in the airway mucosa. A decrease in the number and function of Treg cells is observed in T helper 2 (Th2)-biased allergic airway diseases. However, adoptive transfer of naturally occurring Treg (tTreg) cells or peripherally derived Treg (pTreg) cells in asthmatic mouse models did not yield satisfactory results in any previous studies. Here, we review the recent progress in the identification and plasticity of tTreg and pTreg cells in Th2-biased airway diseases and summarize the factors affecting the stability and function of Treg cells. This review may serve as foundation for understanding the molecular mechanisms underlying the stability of tTreg and pTreg cells and development of effective strategies for treating allergic airway diseases.

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中科院(CAS)分区：

出版当年[2019]版：

大类 | 1 区

医学

小类 | 1 区过敏 2 区免疫学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区免疫学 2 区过敏

JCR分区：

出版当年[2018]版：

Q1 ALLERGY Q1 IMMUNOLOGY

最新[2023]版：

Q1 IMMUNOLOGY Q1 ALLERGY

影响因子： 12.6 最新[2023版] 11.8 最新五年平均 6.771 出版当年[2018版] 7.074 出版当年五年平均 6.048 出版前一年[2017版] 8.706 出版后一年[2019版]

第一作者：

第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Nasal Disease, Beijing Institute of Otolaryngology, Beijing, China [*1]Beijing Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Capital Medical University, No.17, HouGou HuTong, DongCheng District, Beijing 100730, China.

通讯作者：

通讯机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China [2]Beijing Key Laboratory of Nasal Disease, Beijing Institute of Otolaryngology, Beijing, China [*1]Beijing Institute of Otolaryngology, Department of Otolaryngology Head and Neck Surgery, Capital Medical University, No.17, HouGou HuTong, DongCheng District, Beijing 100730, China.

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Stability of regulatory T cells in T helper 2-biased allergic airway diseases

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