机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Centre, BeijingTongren Hospital, Capital Medical University, 1 Dongjiaominxiang Street,Dongcheng District, Beijing 100730, China首都医科大学附属北京同仁医院研究所眼科研究所[2]Beijing Ophthalmology & VisualSciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District,Beijing 100730, China[3]Department of Ophthalmology, Boston UniversitySchool of Medicine, Boston, MA 02118, USA[4]Department of Anatomy andNeurobiology, Boston University School of Medicine, Boston, MA 02118, USA[5]Department of Ophthalmology, Beijing Tongren Eye Centre, Beijing TongrenHospital, Capital Medical University, Beijing 100730, China首都医科大学附属同仁医院
Background To evaluate the macular vessel density (VD) and ganglion cell complex (GCC) thickness in pre-perimetric (PPG) and early perimetric primary open-angle glaucoma (PG) eyes, and to compare the diagnostic ability of the two measurements to discriminate PPG and early PG eyes from healthy eyes. Methods Seventy-nine eyes in 72 subjects (31 normal, 26 PPG, and 22 early PG eyes) were included in the consecutive case series. Macular VD and GCC thickness were acquired simultaneously using the 6 x 6 mm(2) high-density AngioRetina scanning mode. Diagnostic abilities were assessed using the area under the receiver operating characteristic curve (AUROC). Results Compared to healthy eyes, whole image VD (wiVD) and GCC thickness were significantly lower in PPG and early PG eyes (all P < 0.025). The percent reduction of wiVD was lower than that of GCC thickness in early PG eyes (P < 0.05), while they were similar in PPG eyes (P > 0.05). Regionally, greater VD attenuation and GCC thinning were identified in the perifovea than in the parafovea in both groups (all P < 0.05). Moreover, the percent reduction of VD was less than that of GCC thickness in the perifoveal region in PPG eyes (P < 0.05). The AUROCs for wiVD and GCC thickness were 0.824 and 0.881, respectively, in PPG eyes (P > 0.05), and 0.918 and 0.977, respectively, in early PG eyes (P > 0.05). Conclusions Macular VD and GCC thickness significantly decreased in PPG and early PG eyes. The perifoveal region appeared to be more vulnerable to macular VD attenuation and GCC thinning in early glaucoma. Our results showed that macular VD measurements may be helpful for detecting and understanding early glaucomatous damage.
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Centre, BeijingTongren Hospital, Capital Medical University, 1 Dongjiaominxiang Street,Dongcheng District, Beijing 100730, China[2]Beijing Ophthalmology & VisualSciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District,Beijing 100730, China
通讯作者：
通讯机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Centre, BeijingTongren Hospital, Capital Medical University, 1 Dongjiaominxiang Street,Dongcheng District, Beijing 100730, China[2]Beijing Ophthalmology & VisualSciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District,Beijing 100730, China
推荐引用方式(GB/T 7714)：
Wang Yiwei,Xin Chen,Li Meng,et al.Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma[J].BMC OPHTHALMOLOGY.2020,20(1):doi:10.1186/s12886-020-1304-x.
APA：
Wang, Yiwei,Xin, Chen,Li, Meng,Swain, David L.,Cao, Kai...&Wang, Ningli.(2020).Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma.BMC OPHTHALMOLOGY,20,(1)
MLA：
Wang, Yiwei,et al."Macular vessel density versus ganglion cell complex thickness for detection of early primary open-angle glaucoma".BMC OPHTHALMOLOGY 20..1(2020)
