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Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-Targeting of Therapy-Induced Bone Marrow Niches

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收录情况： ◇ SCIE ◇ EI ◇ 自然指数

作者：
Dong, Xiao[1,2] * ; Mu, Li-Li[3] * ; Liu, Xue-Liang[1,2] ; Zhu, Hua[4] ; Yang, Si-Cong[1,2] ; Lai, Xing[1,2] ; Liu, Hai-Jun[1,2] ; Feng, Hai-Yi[1,2] ; Lu, Qin[1,2] ; Zhou, Bin-Bing S.[1,2] ; Chen, Hong-Zhuan[5] ; Chen, Guo-Qiang[6] ; Lovell, Jonathan F.[7] ; Hong, Deng-Li[3] ; Fang, Chao[1,2] ;
机构： [1]Shanghai Jiao Tong Univ, Sch Med, Hongqiao Int Inst Med, Tongren Hosp, Shanghai 200025, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol & Chem Biol, Inst Med Sci, Shanghai 200025, Peoples R China [3]SJTU SM, Key Lab Cell Differentiat & Apoptosis, Shanghai Key Lab Reprod Med, Minist Educ,Shanghai Inst Hematol,Ruijin Hosp,Dep, Shanghai 200025, Peoples R China [4]SJTU SM, Key Lab Pediat Hematol & Oncol, Dept Hematol Oncol, Minist Hlth,Shanghai Childrens Med Ctr, Shanghai 200025, Peoples R China [5]Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Biomed Res, Shanghai 201210, Peoples R China [6]SJTU SM, Key Lab Cell Differentiat & Apoptosis, Minist Educ, Dept Pathophysiol, Shanghai 200025, Peoples R China [7]Univ Buffalo State Univ New York, Dept Biomed Engn, Buffalo, NY 14260 USA
出处：
DOI： 10.1002/adfm.202000309
ISSN：

关键词： bone marrow hypoxia responsive leukemia nanoparticles niche

摘要：
Chemoresistance conferred by leukemia propagating cells (LPCs) in a therapy-induced niche (TI-niche) within the bone marrow is one of the main obstacles in leukemia treatment. Effective approaches to circumvent the TI-niche protection and to eliminate the resident LPCs remain to be exploited. Here, developed is a niche-targeted nanosystem using leukemic cell membrane-coated mesoporous silica nanoparticles (DA(azo)@CMSN) for co-delivering daunorubicin for leukemia cell chemotherapy and a TGF beta RII neutralizing antibody (aTGF beta RII) to block niche signaling. DA(azo)@CMSN effectively targets the TI-niche. Through an azobenzene-based hypoxia-responsive linker, sequential delivery of the two active molecules overcomes niche-mediated chemoresistance, attenuates systemic burden, and prolongs survival in a mouse model of leukemia. This work demonstrates a proof-of-principle for biomimetic and microenvironment-activated multiplexed nanoparticulate drug delivery strategies for overcoming therapy-induced chemoresistance in leukemia.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81572998, 81773274, 81800118, 31872842, 81730007, 81721004, 91442106, 81920108005]; Shanghai Municipal Science and Technology CommissionScience & Technology Commission of Shanghai Municipality (STCSM) [16520710700]; "Shu Guang" Program of Shanghai Education Development Foundation; Shanghai Municipal Education CommissionShanghai Municipal Education Commission (SHMEC) [16SG13]; Chinese Universities Scientific Fund
语种：
外文
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WOS：
中科院(CAS)分区：
出版当年[2019]版：
大类 | 1 区 工程技术
小类 | 1 区 化学综合 1 区 物理化学 1 区 材料科学：综合 1 区 纳米科技 1 区 物理：应用 1 区 物理：凝聚态物理
最新[2025]版：
大类 | 1 区 材料科学
小类 | 1 区 化学：综合 1 区 材料科学：综合 1 区 纳米科技 1 区 物理：应用 1 区 物理：凝聚态物理
JCR分区：
出版当年[2018]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER Q1 NANOSCIENCE & NANOTECHNOLOGY
最新[2023]版：
Q1 CHEMISTRY, MULTIDISCIPLINARY Q1 CHEMISTRY, PHYSICAL Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Q1 NANOSCIENCE & NANOTECHNOLOGY Q1 PHYSICS, APPLIED Q1 PHYSICS, CONDENSED MATTER

影响因子： 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

第一作者：
第一作者机构： [1]Shanghai Jiao Tong Univ, Sch Med, Hongqiao Int Inst Med, Tongren Hosp, Shanghai 200025, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol & Chem Biol, Inst Med Sci, Shanghai 200025, Peoples R China
共同第一作者：
通讯作者：
通讯机构： [1]Shanghai Jiao Tong Univ, Sch Med, Hongqiao Int Inst Med, Tongren Hosp, Shanghai 200025, Peoples R China [2]Shanghai Jiao Tong Univ, Sch Med, Dept Pharmacol & Chem Biol, Inst Med Sci, Shanghai 200025, Peoples R China
推荐引用方式(GB/T 7714)：
Dong Xiao,Mu Li-Li,Liu Xue-Liang,et al.Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-Targeting of Therapy-Induced Bone Marrow Niches[J].ADVANCED FUNCTIONAL MATERIALS.2020,30(12):doi:10.1002/adfm.202000309.
APA：
Dong, Xiao,Mu, Li-Li,Liu, Xue-Liang,Zhu, Hua,Yang, Si-Cong...&Fang, Chao.(2020).Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-Targeting of Therapy-Induced Bone Marrow Niches.ADVANCED FUNCTIONAL MATERIALS,30,(12)
MLA：
Dong, Xiao,et al."Biomimetic, Hypoxia-Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co-Targeting of Therapy-Induced Bone Marrow Niches".ADVANCED FUNCTIONAL MATERIALS 30..12(2020)

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