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Sulforaphane attenuates angiotensin II-induced human umbilical vein endothelial cell injury by modulating ROS-mediated mitochondrial signaling

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收录情况： ◇ SCIE

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机构： [1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Div Cardiol, Shanghai, Peoples R China

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关键词： Sulforaphane angiotensin II human umbilical vein endothelial cells oxidative stress Nrf2

摘要：

The study aimed to investigate whether sulforaphane (SFN) protects against angiotensin II (Ang II)-mediated human umbilical vein endothelial cell (HUVEC) injury. Ang II treatment decreased HUVEC viability, increased cell apoptosis, decreased mitochondria membrane potential (MMP), impaired cytochrome c release, activated caspase 3/9, and induced reactive oxygen species (ROS) production, and nicotinamide adenine dinucleotide phosphate oxidase activity. Moreover, SFN treatment blunted Ang II-stimulated oxidative stress and mitochondria-related apoptosis in HUVECs. The ROS scavenger N-acetyl-l-cysteine reduced Ang II-induced oxidative stress and apoptosis, indicating that ROS generation is involved in the Ang II-induced mitochondria-mediated apoptotic pathway. SFN induced nuclear factor erythroid 2 (Nrf2) activation and expression in Ang II-stimulated HUVECs. Downregulation of Nrf2 expression by a target-specific siRNA revealed an Nrf2-dependent effect on the SFN-mediated attenuation of Ang II-induced apoptosis in HUVECs. Pretreatment with brusatol, an Nrf2-specific inhibitor, reversed the protective effects of SFN on Ang II-induced HUVEC injury. SFN treatment protected HUVECs from Ang II-induced damage by decreasing oxidative stress and ameliorating mitochondrial injury.

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出版当年[2019]版：

大类 | 4 区医学

小类 | 4 区毒理学

最新[2025]版：

大类 | 4 区医学

小类 | 4 区毒理学

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出版当年[2018]版：

Q3 TOXICOLOGY

最新[2023]版：

Q3 TOXICOLOGY

影响因子： 2.7 最新[2023版] 3 最新五年平均 2.171 出版当年[2018版] 1.969 出版当年五年平均 1.84 出版前一年[2017版] 2.067 出版后一年[2019版]

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第一作者机构： [1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Div Cardiol, Shanghai, Peoples R China

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通讯机构： [1]Shanghai Jiao Tong Univ, Sch Med, Shanghai Tongren Hosp, Div Cardiol, Shanghai, Peoples R China [*1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Div Cardiol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China

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