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Ablation Versus Medical Therapy for Atrial Fibrillation in the Elderly: A Propensity Score-Matched Comparison

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机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Natl Clin Res Ctr Cardiovasc Dis, Dept Cardiol, Beijing, Peoples R China [2]Shanxi Cardiovasc Hosp, Dept Cardiol, Taiyuan, Shanxi, Peoples R China [3]Capital Med Univ, Tongren Hosp, Cardiovasc Ctr, Beijing, Peoples R China [4]Beijing Univ, Clin Res Inst, Beijing, Peoples R China
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关键词: Atrial Fibrillation Catheter Ablation China Propensity Score

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Background: Whether ablation therapy reduces the risk of death and embolic events in elderly patients with atrial fibrillation (AF) remains unclear. Material/Methods: AF patients >= 65 years old receiving either catheter ablation or non-ablation therapy at 2 tertiary and 2 non- tertiary hospitals in Beijing from November 2009 to December 2012 were enrolled. Patients were followed up every 6 months for information on treatment and clinical event occurrence. A propensity score matching algorithm produced comparable 2 groups of patients treated with ablation or non-ablation. Rates of a composite of all-cause death, non-fatal stroke, and peripheral embolism were the primary outcomes. Each composite component and major bleeding were the secondary outcomes. Results: There were 596 ablated patients and 1144 patients with non-ablation therapy enrolled. Propensity score algorithm matched 347 comparable pairs of patients. Patient characteristics variables were well balanced. During 523.5 and 497.5 patient-years follow-up, respectively, ablation therapy was associated with a significant lower risk of experiencing the primary composite outcome (hazard ratio [HR]=0.40; 95% confidence interval [CI]: 0.19-0.85), all-cause death (HR=0.13 95% CI: 0.04-0.43), and major bleeding (HR=0.23; 95% CI: 0.12-0.67), without apparent heterogeneity by age, sex, and AF type, and for risk score subgroups. Conclusions: In this propensity-matched elderly sample, ablation therapy was associated with lower risk of composite out- come consisting of all-cause death, non-fatal stroke, and peripheral embolism, and therefore might be an alternative to conservative therapy.

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出版当年[2018]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 医学:研究与实验
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出版当年[2017]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版:
Q3 MEDICINE, RESEARCH & EXPERIMENTAL

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第一作者机构: [1]Capital Med Univ, Beijing Anzhen Hosp, Natl Clin Res Ctr Cardiovasc Dis, Dept Cardiol, Beijing, Peoples R China [2]Shanxi Cardiovasc Hosp, Dept Cardiol, Taiyuan, Shanxi, Peoples R China
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