The nasal mucociliary clearance system, which comprises epithelial cilia and mucus from goblet cells, is an important intrinsic defense mechanism of the upper respiratory tract. Intranasal drugs and additives can have a detrimental effect on ciliary activity and mucociliary clearance, and thus impact the integrity of nasal defense mechanisms. This article discusses the current literature on the effects of different classes of intranasal drugs including intranasal corticosteroids, antihistamines, decongestants, antimicrobials and antivirals, as well as various drug excipients and nasal irrigation solutions on human nasal mucociliary clearance and ciliary beat frequency. Available data indicate that some intranasal formulations tend to hamper nasal ciliary function and mucociliary clearance. Therefore, it is of great importance to assess the effects of intranasal drugs and additives on mucociliary function before they are recommended as therapy for different nasal conditions.
基金：
National Key R&D Program of China [2016YFC20160905200]; Program for the Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81420108009, 81400444, 81470678, 81630023]; Natural Science Foundation of BeijingBeijing Natural Science Foundation [7172053]; Beijing Municipal Administration of Hospitals' Mission Plan [SML20150203]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [ZYLX201310]; Beijing Health Bureau Program for High Level Talents [2014-3-018]; Beijing Municipal Science & Technology Commission ProjectBeijing Municipal Science & Technology Commission [Z141107002514122]; Beijing Advanced Innovation Center for Food Nutrition and Human Health (Beijing Technology and Business University) [20181045]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, 17 Hougou Hutong, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, 17 Hougou Hutong, Beijing 100005, Peoples R China[*1]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, No. 17, Hougou Hutong, Dongcheng District, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Jiao Jian,Zhang Luo.Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency[J].ALLERGY ASTHMA & IMMUNOLOGY RESEARCH.2019,11(3):306-319.doi:10.4168/aair.2019.11.3.306.
APA：
Jiao, Jian&Zhang, Luo.(2019).Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency.ALLERGY ASTHMA & IMMUNOLOGY RESEARCH,11,(3)
MLA：
Jiao, Jian,et al."Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency".ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 11..3(2019):306-319
