LncRNAs are involved in the initiation and progression of cancer. However, the molecular mechanism and diverse clinical prognosis of MIR31HG in head and neck squamous cell carcinoma (HNSCC) are still unclear. Our previous microarray analysis showed that lncRNA MIR31HG interacted with HIF1A may play an oncogenic role in laryngeal squamous cell cancer (LSCC). To determine whether lncRNA MIR31HG served as a poor prognosis factor and targeted HIF1A to facilitate cell proliferation and tumorigenesis in human HNSCC, we found MIR31HG and HIF1A were overexpressed in LSCC, MIR31HG overexpression or co-expression of HIF1A-positive and p21-negative could serve as a poor prognostic factor for LSCC patients. We further confirmed that MIR31HG promoted cell proliferation, cell cycle progression, and inhibited cell apoptosis in vitro and in vivo. The ingenuity pathway analysis and Western blot indicated that MIR31HG regulated cell cycle progression via HIF1A and p21 in HNSCC. The current results provide evidences for the role of MIR31HG in promoting HNSCC progression and identify MIR31HG as a prognostic biomarker and putative therapeutic target in HNSCC.
基金：
Beijing Natural Science Foundation (7184196),
National Natural Science Foundation of China (81473499), Beijing Municipal
Administration of Hospitals’ Ascent Plan (DFL20180202), and the Priming
Scientific Research Foundation for the Junior Researcher in Beijing Tongren
Hospital, Capital Medical University (2017-YJJ-ZZL-001).
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Minist Educ China, Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[2]Minist Educ China, Beijing Inst Otolaryngol, Key Lab Otolaryngol Head & Neck Surg, Beijing 100005, Peoples R China[3]Beijing Key Lab Head & Neck Mol Diagnost Pathol, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Ru,Ma Zhihong,Feng Ling,et al.LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression[J].MOLECULAR CANCER.2018,17:doi:10.1186/s12943-018-0916-8.
APA：
Wang, Ru,Ma, Zhihong,Feng, Ling,Yang, Yifan,Tan, Chen...&Fang, Jugao.(2018).LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression.MOLECULAR CANCER,17,
MLA：
Wang, Ru,et al."LncRNA MIR31HG targets HIF1A and P21 to facilitate head and neck cancer cell proliferation and tumorigenesis by promoting cell-cycle progression".MOLECULAR CANCER 17.(2018)
医学