机构：[1]Department of Oncology, People's Liberation Army 105 Hospital, Hefei, Anhui 230031[2]Hongqiao International Institute ofMedicine, Shanghai Tongren Hospital/Faculty of Public Health[3]Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200025[4]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223[5]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204[6]Kunming Biological Diversity Regional Center of Instruments, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China
Hepatocellular carcinoma (HCC) is one of the most lethal and malignant types of cancer that affects global human health. The present study aimed to investigate the effect of pyruvate kinase muscle isozyme M2 (PKM2) expression on the clinical features and prognosis of HCC. The present study employed univariate logistic regression to investigate the correlation between PKM2 expression and clinical features. Univariate and multivariate Cox regression analyses were performed to estimate the independent effect of PKM2 expression on survival status. The results revealed that patients in the high PKM2 group (11.25) exhibited significantly lower creatinine levels (P=0.043), higher fetoprotein levels (P<0.001), advanced stage (P<0.001) and higher grade (P=0.004) compared with patients with low PKM2 expression levels (<11.25). In addition, patients with high PKM2 expression exhibited poor prognosis compared with patients with low PKM2 expression. After correcting the covariates, PKM2 expression remains significantly associated with reduced overall survival (P<0.05). These findings suggested that PKM2 is an independent risk factor for HCC and provides valuable information for future studies on the pathogenesis of HCC and drug discovery.
基金：
Anhui Provincial Natural Science FoundationNatural Science Foundation of Anhui Province [1808085MH239]; Instruments Function Deployment Foundation of CAS [2014g0019, 2016g0049, 2017gz005]; CAS Key Technology Talent Program
第一作者机构：[1]Department of Oncology, People's Liberation Army 105 Hospital, Hefei, Anhui 230031
共同第一作者：
通讯作者：
通讯机构：[4]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223[5]Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204[6]Kunming Biological Diversity Regional Center of Instruments, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, P.R. China[*1]Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, P.R. China[*2]Kunming Biological Diversity Regional Center of Instruments, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming, Yunnan 650223, P.R. China
推荐引用方式(GB/T 7714)：
Lu Dong-Hui,Lv Wen-Wen,Li Wen-Xing,et al.High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma[J].ONCOLOGY LETTERS.2018,16(3):3603-3610.doi:10.3892/ol.2018.9100.
APA：
Lu, Dong-Hui,Lv, Wen-Wen,Li, Wen-Xing&Gao, Yue-Dong.(2018).High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma.ONCOLOGY LETTERS,16,(3)
MLA：
Lu, Dong-Hui,et al."High PKM2 expression is independently correlated with decreased overall survival in hepatocellular carcinoma".ONCOLOGY LETTERS 16..3(2018):3603-3610
