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Morphine and sufentanil treatment alters microRNA profiling in neurons

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [2]State Key Laboratory of Membrane Biology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China [3]Hendrix College, 1600 Washington Ave. Conway Arkansas 72032, USA [4]Wuhan University, College of Life Sciences, Wuhan 430027, China

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关键词： Morphine sufentanil microRNA anesthetics Alzheimer's disease profiling

摘要：

Opioids are morphine-like substances that bind to opioid receptors and are often used to relieve pain. Whether this kind of drugs, including natural product morphine and synthetic product sufentanil, have a protective or destructive effect on nervous system is still unclear. Here, we investigated the alterations of microRNA expression profile after morphine and sufentanil treatment in cultured mouse neurons using microarray. Five microRNA upregulated and 15 microRNA downregulated after morphine treatment and 5 microRNA upregulated and 5 microRNA downregulated after sufentanil treatment with the cutoff of 2-fold change. Our data suggest that microRNA alteration may be involved in opioid drugs' effects in the central nervous system.

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出版当年[2017]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2016]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 0.2 最新[2023版] 0.2 最新五年平均 1.069 出版当年[2016版] 1.091 出版当年五年平均 1.075 出版前一年[2015版] 0.833 出版后一年[2017版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

通讯作者：

通讯机构： [1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China [*1]Department of Anesthesiology, Beijing Tongren Hospi-tal, Capital Medical University, Beijing 100730, China.

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