Propofol can be protective against various insults in many systems. However, the exact mechanisms of propofol protection are still unknown. In the present study, we showed that propofol decreased p53 level through upregulating miR-6983-5p. This might be a possible mechanism of propofol promoting cell survival. In addition, propofol prevented neurons against staurosporine, etoposid, glutamate and serum deprivation treatments. Our study provides a possible mechanism that propofol regulating p53 level through miRNA to prevent cell death.
基金：
National
Science Foundation of China (NSFC) Research
Grant (81301131, 81571037 and 81671044).
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Anesthesiol, Beijing 100730, Peoples R China[*1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Pan Chuxiong,Shu Luowa,Chen Zhiya,et al.Propofol decreases p53 levels to prevent cell death[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(11):22069-22075.
APA：
Pan, Chuxiong,Shu, Luowa,Chen, Zhiya&Wang, Yu.(2016).Propofol decreases p53 levels to prevent cell death.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9,(11)
MLA：
Pan, Chuxiong,et al."Propofol decreases p53 levels to prevent cell death".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9..11(2016):22069-22075
