机构：[1]Hendrix College, 1600 Washington Ave, Conway Arkansas 72032, The U.S.[2]State Key Laboratory of MembraneBiology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing100871, China[3]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing100730, China临床科室麻醉科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Propofol is one of a commonly used intravenous anesthetics. Many studies have shown that propofol can protect the cells from apoptosis by regulating different miRNA. In this study, we found that propofol decreased p53 level via upregulating miR-592-5p. The technique used were real time PCR, western blots and luciferase reporter assay. Moreover, we also found that propofol prevented neurons against actinomycin D, extracellular amyloid beta, TNF-alpha and H2O2 treatments. This study shown that miR-592-5p could be regulated by propofol on preventing cell death.
基金：
National
Science Foundation of China (NSFC) Research
Grant (81301131, 81571037 and 81671044).
第一作者机构：[1]Hendrix College, 1600 Washington Ave, Conway Arkansas 72032, The U.S.
通讯作者：
通讯机构：[3]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing100730, China[*1]Department of Anesthesiology, Beijing Tongren Hospital, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Sun Yunong,Chen Zhiya,Pan Chuxiong.Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2017,10(2):3953-3958.
APA：
Sun, Yunong,Chen, Zhiya&Pan, Chuxiong.(2017).Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,10,(2)
MLA：
Sun, Yunong,et al."Propofol inhibits neuronal apotosis by decreasing p53 levels via upregulating miR-592-5p".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 10..2(2017):3953-3958
