机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室麻醉科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China[3]Department of Neurobiology and Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[4]State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China
Propofol is a short-acting intravenous anesthetics. Whether propofol application and treatment induce destructive or protective effects is still in dispute. MicroRNA alterations have been observed in various physiological and pathological processes. We now report the alterations of microRNA profile after propofol treatment in primarily cultured mouse hippocampal neurons. Among 1908 mouse microRNAs examined, there are 40 microRNAs upregulated and 54 microRNAs downregulated with the cutoff as 2 fold change. Our data shed a light on how propofol may play roles via regulating microRNAs.
基金：
National Natural Science Foundation of
China (81301131 and 81571037).
第一作者机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
通讯作者：
通讯机构：[1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[2]Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China[3]Department of Neurobiology and Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China[*1]Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China[*2]Department of Anesthesiology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China[*3]Department of Neurobiology and Center of Stroke, Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Shu Luowa,Yan Xing,Cui Xu,et al.Propofol treatment alters microRNA profiling in neurons[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2016,9(6):11292-11298.
APA：
Shu, Luowa,Yan, Xing,Cui, Xu,Zhou, Dingxi,Li, Junfa...&Pan, Chuxiong.(2016).Propofol treatment alters microRNA profiling in neurons.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,9,(6)
MLA：
Shu, Luowa,et al."Propofol treatment alters microRNA profiling in neurons".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 9..6(2016):11292-11298
