Background and aim: Beclin1 has been reported as a vital marker for a number of malignant tumors. However, the role of Beclin1 in hepatocellular carcinoma (HCC) remains inconclusive. Thus, we conducted a meta-analysis to assess the correlation between Beclin1 and its clinicopathological and prognostic values in HCC. Methods: PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI, and Chinese WanFang databases were searched for published articles on Beclin1 expression in hepatocellular tissues. Standard-compliant articles were screened using the Newcastle-Ottawa Scale for strict quality control of the literature. The correlation of Beclin1 expression with the clinicopathological features and survival outcomes was analyzed. Pooled odds ratios and hazard ratios with 95% confidence intervals were calculated using STATA14.2. Results: Eleven articles with 1,279 patients were included in this meta-analysis. Positive Beclin1 expression was found to be correlated with alpha fetoprotein, liver cirrhosis, and vascular invasion, but not with gender, age, HBsAg, size of tumor, number of tumors, differentiation, and TNM stage. Positive Beclin1 expression was also associated with favorable 5-year overall survival and disease-free survival rates. Conclusion: Our meta-analysis indicated that positive Beclin1 expression was negatively related to alpha fetoprotein, liver cirrhosis, and vascular invasion in HCC. Beclin1 could be used as a prognostic biomarker for HCC.
基金:
Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support [ZYLX201612]; Capital Foundation of Medical Development [shoufa2016-2-2053]
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Gen Surg, 2 Chongwenmennei St, Beijing 100730, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Gen Surg, 2 Chongwenmennei St, Beijing 100730, Peoples R China[*1]Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, No 2 Chongwenmennei Street, Dongcheng, Beijing, 100730, People’s Republic of China
推荐引用方式(GB/T 7714):
Liang Chaojie,Li Wei,Ge Hua,et al.Role of Beclin 1 expression in patients with hepatocellular carcinoma: a meta-analysis[J].ONCOTARGETS AND THERAPY.2018,11:2387-2397.doi:10.2147/OTT.S151751.
APA:
Liang, Chaojie,Li, Wei,Ge, Hua,Zhang, Kaitong,Li, Guangming&Wu, Jixiang.(2018).Role of Beclin 1 expression in patients with hepatocellular carcinoma: a meta-analysis.ONCOTARGETS AND THERAPY,11,
MLA:
Liang, Chaojie,et al."Role of Beclin 1 expression in patients with hepatocellular carcinoma: a meta-analysis".ONCOTARGETS AND THERAPY 11.(2018):2387-2397