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Caerulin-induced pro-inflammatory response in macrophages requires TRAF3-p38 signaling activation

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收录情况： ◇ SCIE

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机构： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol, Tongren Hosp, 1111 Xianxia St, Shanghai 200336, Peoples R China

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关键词： Acute pancreatitis Caerulin TRAF3 Pro-inflammatory responses Macrophages p38

摘要：

Acute pancreatitis is a common threat to human health. Caerulin provokes severe inflammations, causing injuries to surrounding pancreatic cells. TNF receptor-associated factor 3 (TRAF3) is a highly versatile regulator of immune response. The current study aims to understand the potential effect of TRAF3 on caerulin-induced pro-inflammatory responses. In the primary-cultured mouse bone marrow-derived macrophages (BMDMs), caerulin induced TRAF3 protein stabilization, which formed a complex with mitogen-activated protein kinase kinase 3 (MKK3) to mediate downstream p38 activation. Lentiviral shRNA-mediated TRAF3 stable knockdown significantly attenuated caerulin-induced MKK3-p38 activation and production of several key pro-inflammatory cytokines, including interleukin-1 beta (IL-1 beta), tumor necrosis factor-a (TNF-alpha) and IL-17. Remarkably, TRAF3 knockdown in caerulin-stimulated BMDMs also alleviated cytotoxicity to Panc02 and primary mouse pancreatic cells. Thus, TRAF3 is required for caerulin-induced p38 activation and macrophage-mediated pro-inflammatory responses. TRAF3 expression in macrophages could be a novel therapeutic target protein for the treatment of acute pancreatitis. (C) 2017 Elsevier Inc. All rights reserved.

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出版当年[2016]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2025]版：

大类 | 4 区生物学

小类 | 4 区生化与分子生物学 4 区生物物理

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出版当年[2015]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.371 出版当年[2015版] 2.392 出版当年五年平均 2.297 出版前一年[2014版] 2.466 出版后一年[2016版]

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol, Tongren Hosp, 1111 Xianxia St, Shanghai 200336, Peoples R China

通讯作者：

通讯机构： [1]Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol, Tongren Hosp, 1111 Xianxia St, Shanghai 200336, Peoples R China [*1]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, The 1111 Xianxia Street, Shanghai, 200336, China

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