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Feedback autophagy activation as a key resistance factor of Ku-0060648 in colorectal cancer cells

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收录情况： ◇ SCIE

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机构： [1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Emergency Ctr, 1111 Xianxia St, Shanghai 200336, Peoples R China

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关键词： Colorectal cancer Ku-0060648 Autophagy DNA-PKcs PI3K-AKT-mTOR

摘要：

The current study evaluated the potential anti-colorectal cancer (CRC) activity by Ku-0060648, a novel DNA-PKcs and PI3K duel inhibitor. In both CRC cell lines (HCT-116 and HT-29) and primary human colon cancer cells, Ku-0060648 exposure at nM concentrations efficiently inhibited cell proliferation. Meanwhile, Ku-0060648 provoked apoptosis in CRC cells. Ku-0060648 was yet ineffective to the normal colon epithelial cells. Ku-0060648 blocked PI3K-AKT-mTOR cascade and in-activated DNA-PKcs in CRC cells. Intriguingly, Ku-0060648 treatment induced feedback autophagy activation in HCT-116 cells. On the other hand, pharmacological autophagy inhibitors (3-methyladenine or chloroquine) or silencing key autophagy proteins (Beclin-1 or ATG-7) dramatically potentiated Ku-0060648-induced HCT-116 cell apoptosis. Together, these results suggest that feedback autophagy activation is a key resistance factor of Ku-0060648 in CRC cells, and autophagy inhibition sensitizes Ku-0060648-induced anti-CRC activity. (C) 2017 Elsevier Inc. All rights reserved.

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出版当年[2016]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

JCR分区：

出版当年[2015]版：

Q2 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.371 出版当年[2015版] 2.392 出版当年五年平均 2.297 出版前一年[2014版] 2.466 出版后一年[2016版]

第一作者：

第一作者机构： [1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Emergency Ctr, 1111 Xianxia St, Shanghai 200336, Peoples R China

通讯作者：

通讯机构： [1]Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Emergency Ctr, 1111 Xianxia St, Shanghai 200336, Peoples R China [*1]Emergency Center, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Street, Shanghai, 200336, China.

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