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Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011

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收录情况： ◇ SCIE

作者：
Jie, Ren[1] * ; Xu, Liang[1,*1] ; Wang, Ya Xing[1] ; Zhang, Li[1] ; You, Qi Sheng[1] ; Yang, Hua[1] ; Jonas, Jost B.[1,2,*2] ;
机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China [2]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany
出处：
DOI： 10.1167/iovs.15-16682
ISSN：

关键词： retinal nerve fiber layer stroke glaucoma optic nerve optic disc Beijing Eye Study

摘要：
PURPOSE. We examined the 10-year incidence of localized retinal nerve fiber layer defects (RNFLDs) and associated factors in adult Chinese. METHODS. The population-based longitudinal Beijing Eye Study, which included 4439 subjects (age, 40+ years) in 2001, was repeated in 2011 with 2695 subjects participating (66.4% of the survivors). Color fundus photographs taken at baseline and 10 years later were examined for localized RNFLDs, defined as wedge-shaped defects running toward the optic disc. RESULTS. Fundus photographs were available for 2422 (89.9%) subjects. Incident-localized RNFLDs were detected in 114/2422 persons (4.7% +/- 0.2%) or 139/4867 eyes (2.9% +/- 0.2%). A total of 25 (22%) persons had incident-localized RNFLDs bilaterally, and 89 (78%) persons unilaterally. Among the 114 persons with incident RNFLDs, 78 persons showed newly developed localized RNFLDs, while 36 subjects showed an enlargement of a preexisting localized RNFLD. In binary logistic regression analysis, a higher 10-year incidence of localized RNFLDs was significantly associated with a higher prevalence of arterial hypertension (P = 0.002; odds ratio [OR], 2.31; 95% confidence interval (CI), 1.35, 3.97), higher diastolic blood pressure (P = 0.02; OR, 1.02; 95% CI, 1.004,1.04), higher prevalence of previous cerebrovascular infarctions (P = 0.007; OR, 2.61; 95% CI, 1.30, 5.22), younger age (P = 0.01; OR, 0.97; 95% CI, 0.94, 0.99), higher prevalence of diabetic retinopathy (P = 0.001; OR, 4.70; 95% CI, 1.92, 11.5), higher prevalence of open-angle (P < 0.001; OR, 39.8; 95% CI, 19.7, 80.5) and angle-closure (P < 0.001; OR, 21.3; 95% CI, 7.90, 57.5) glaucoma, and thinner retinal nerve fiber layer (P < 0.001; OR, 0.97; 95% CI, 0.95, 0.98). CONCLUSIONS. The 10-year incidence of localized RNFLDs in adult Chinese is 4.7% +/- 0.2%. It is strongly associated with arterial hypertension and higher prevalence of cerebrovascular infarcts, in addition to ocular reasons, such as glaucoma and diabetic retinopathy. Ophthalmologically normal subjects with incident-localized RNFLDs may be screened for arterial hypertension and cerebrovascular infarcts.

基金：
State Natural Sciences Fund (81041018), Natural Sciences Fund of Beijing Government (7092021;7112031), and the National Key Technology R&D Program of the Ministry of Science and Technology (Nos. 2012BAH05F05 and 2013BAH19F04).
语种：
外文
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中科院(CAS)分区：
出版当年[2014]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 眼科学
JCR分区：
出版当年[2013]版：
Q1 OPHTHALMOLOGY
最新[2023]版：
Q1 OPHTHALMOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2013版] 出版当年五年平均 出版前一年[2012版] 出版后一年[2014版]

第一作者：
第一作者机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China
通讯作者：
通讯机构： [1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Science Key Lab, Capital Medical University, Beijing, China [2]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Heidelberg, Germany [*1]Beijing Institute of Ophthalmology, 17 Hougou Lane, Chong Wen Men, 100005 Beijing, China [*2]Adenauerplatz 2, 69115 Heidelberg, Germany
推荐引用方式(GB/T 7714)：
Jie Ren,Xu Liang,Wang Ya Xing,et al.Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2015,56(9):5118-5124.doi:10.1167/iovs.15-16682.
APA：
Jie, Ren,Xu, Liang,Wang, Ya Xing,Zhang, Li,You, Qi Sheng...&Jonas, Jost B..(2015).Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,56,(9)
MLA：
Jie, Ren,et al."Ten-Year Incidence of Retinal Nerve Fiber Layer Defects: The Beijing Eye Study 2001/2011".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 56..9(2015):5118-5124

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