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F-box protein Fbxo3 targets Smurf1 ubiquitin ligase for ubiquitination and degradation

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收录情况： ◇ SCIE

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机构： [1]Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing 100730, China [2]State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, No. 27 Taiping Road, Beijing 100850, China [3]Department of Ultrasound, Peking University Shougang Hospital, No.9 Jinyuanzhuang Road, Shijingshan District, Beijing 100144, China

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关键词： Protein ubiquitination Proteasomal degradation Ubiquitin ligase Fbxo3 Smurf1

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It has been demonstrated previously that F-box protein Fbxl15 targets HECT-type E3 Smurf1 and forms a functionally active SCF complex for ubiquitination and proteasomal degradation. Here we show that another F-box protein Fbxo3, belonging to the FBXO type protein family, also interacts with and targets Smurf1 for poly-ubiquitination and proteasomal degradation. Different from Fbx115, Fbxo3 targets all the Nedd4 family members for their degradation, indicating that Fbxo3 plays an important role in controlling the stability of Nedd4. Taken together, we show that Smurfl is an endogenous substrate of Fbxo3. Our study gains further insight into the novel role of Fbxo3 in BMP signaling. (C) 2015 Elsevier Inc. All rights reserved.

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出版当年[2014]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

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出版当年[2013]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.281 出版当年[2013版] 2.474 出版当年五年平均 2.406 出版前一年[2012版] 2.297 出版后一年[2014版]

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第一作者机构： [1]Department of Gastroenterology, Beijing Tongren Hospital, Capital Medical University, No.1 Dongjiaominxiang, Dongcheng District, Beijing 100730, China

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