Objective This study was to analyze the interobserver histopathological variability and carcinoma transformation of laryngeal premalignant lesions. Study Design A historical cohort study. Setting Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing, China. Subjects and Methods kappa-statistics analysis was performed to estimate interobserver histopathological variability among pathologists by reassessment of 237 cases with laryngeal premalignant lesion according to 2005 WHO classification system. A retrospective follow-up of 237 patients over 8-year duration was carried out, and the carcinoma transformation of laryngeal premalignant lesions was analyzed using Kaplan-Meier survival curve estimation. Results kappa-values of 0.5989 concerning interobserver variability indicated a moderate agreement among 3 pathologists. Major source of intergrade diagnostic disagreement between the original and the consensus diagnoses involved 2 grade pairs, namely, mild and moderate dysplasia, severe dysplasia, and carcinoma in situ. In addition, follow-up study showed that 20 of 237 (8.44%) laryngeal premalignant lesion cases developed into invasive carcinoma. Carcinoma transformation in severe dysplasia group exhibited a similar risk compared to that in carcinoma in situ group (P = .232). Conclusion Severe dysplasia shows the same carcinoma transformation potential as the carcinoma in situ does. Clinically, more attention to severe dysplasia is needed in comparison with mild and moderate dysplasia.
基金：
Health System High Level Health Technical Personnel Training Plan of Beijing City
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Pathol, Beijing 100730, Peoples R China[2]Capital Med Univ, Beijing LuHe Teaching Hosp, Dept Pathol, Beijing 100730, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Pathol, Beijing 100730, Peoples R China[*1]Department of Pathology, Beijing TongRen Hospital, Capital Medical University, Beijing, 100730, China.
推荐引用方式(GB/T 7714)：
Hu Yanping,Liu Honggang.Diagnostic Variability of Laryngeal Premalignant Lesions: Histological Evaluation and Carcinoma Transformation[J].OTOLARYNGOLOGY-HEAD AND NECK SURGERY.2014,150(3):401-406.doi:10.1177/0194599813516733.
APA：
Hu, Yanping&Liu, Honggang.(2014).Diagnostic Variability of Laryngeal Premalignant Lesions: Histological Evaluation and Carcinoma Transformation.OTOLARYNGOLOGY-HEAD AND NECK SURGERY,150,(3)
MLA：
Hu, Yanping,et al."Diagnostic Variability of Laryngeal Premalignant Lesions: Histological Evaluation and Carcinoma Transformation".OTOLARYNGOLOGY-HEAD AND NECK SURGERY 150..3(2014):401-406
