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DcR3 regulates the growth and metastatic potential of SW480 colon cancer cells

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收录情况： ◇ SCIE

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机构： [1]Capital Med Univ, Ctr Clin Pathol, Beijing 100069, Peoples R China [2]Capital Med Univ, Beijing Anzhen Hosp, Dept Gen Surg, Beijing 100029, Peoples R China [3]Beijing Aerosp Gen Hosp, Dept Pathol, Beijing 100076, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Beijing 100730, Peoples R China

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关键词： DcR3 colon cancer RNAi MMPs VEGFs

摘要：

Decoy receptor 3 (DcR3) is considered to have anti-apoptotic and pro-metastatic functions, suggesting it might be a therapeutic target. We examined the role and mechanisms of DcR3 on growth and the metastatic ability of SW480 colon cancer cells to provide therapeutic information for targeting DcR3 by RNA interference (RNAi) technology. Growth and the metastatic ability were inhibited, apoptosis was induced and cell cycle profile was changed after decreasing DcR3 expression, with lower levels of vascular endothelial growth factors (VEGFs) and matrix metalloproteinases (MMPs) expression. Our results implied the therapeutic potential of silencing DcR3 expression by RNAi in colon cancer.

基金：

基金编号： 30972886

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出版当年[2012]版：

大类 | 4 区医学

小类 | 4 区肿瘤学

最新[2025]版：

大类 | 3 区医学

小类 | 4 区肿瘤学

JCR分区：

出版当年[2011]版：

Q3 ONCOLOGY

最新[2023]版：

Q2 ONCOLOGY

影响因子： 3.8 最新[2023版] 3.4 最新五年平均 1.835 出版当年[2011版] 1.827 出版当年五年平均 1.686 出版前一年[2010版] 2.297 出版后一年[2012版]

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第一作者机构： [1]Capital Med Univ, Ctr Clin Pathol, Beijing 100069, Peoples R China

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通讯作者：

通讯机构： [1]Capital Med Univ, Ctr Clin Pathol, Beijing 100069, Peoples R China [4]Capital Med Univ, Beijing Tongren Hosp, Beijing 100730, Peoples R China [*1]Center for Clinical Pathology, Capital Medical University, no. 10 Xitoutiao, You An Men, Fengtai, Beijing 100069, P.R. China [*2]Beijing Tongren Hospital, Capital Medical University, no. 2 Chongwenmennei Street, Dongcheng, Beijing 100730, P.R. China

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