ASSOCIATION OF GLUTATHIONE S-TRANSFERASE PI ISOFORM SINGLE-NUCLEOTIDE POLYMORPHISMS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN A CHINESE POPULATION
Purpose: To investigate the association between single-nucleotide polymorphisms in the pi isoform of glutathione S-transferase (GSTP1) gene and the risk of exudative age-related macular degeneration (AMD) in a Chinese case-control cohort. Methods: A total of 131 Chinese patients with exudative AMD and 138 control individuals were recruited. Genomic DNA was extracted from venous blood leukocytes. Two common nonsynonymous single-nucleotide polymorphisms in GSTP1 (rs1695 and rs1138272) were genotyped by polymerase chain reaction followed by allele-specific restriction enzyme digestion and direct sequencing. Results: Significant association with exudative AMD was detected for single-nucleotide polymorphism, rs1695 (P = 0.019). The risk G allele frequencies were 21.8% in AMD patients and 12.7% in control subjects (P = 0.007). Compared with the wild-type AA genotype, odds ratio for the risk of AMD was 1.91 (95% confidence interval, 1.09-3.35) for the heterozygous AG genotype and 2.52 (95% confidence interval, 0.6-10.61) for the homozygous GG genotype. In contrast, rs1138272 was not associated with exudative AMD (P = 1.00). The risk G allele frequencies of rs1138272 were 0.4% in AMD patients and 0.4% in control subjects (P = 1.00). Conclusion: Our data suggest that the GSTP1 variant rs1695 moderately increases the risk of exudative AMD. The variant rs1138272 was rare and was not associated with exudative AMD in this Chinese cohort. RETINA 32:1967-1972, 2012
基金:
National Basic Research Program of China (973 Program)National Basic Research Program of China [2007CB512201]; Beijing Education Commission [KZ201110025028]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81070734]
第一作者机构:[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China[*1]Capital Med Univ, Beijing Tongren Eye Ctr, Beijing Tongren Hosp, Beijing Ophthalmol & Visual Sci Key Lab, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714):
Gu Hong,Sun Erdan,Cui Lei,et al.ASSOCIATION OF GLUTATHIONE S-TRANSFERASE PI ISOFORM SINGLE-NUCLEOTIDE POLYMORPHISMS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN A CHINESE POPULATION[J].RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES.2012,32(9):1967-1972.doi:10.1097/IAE.0b013e31824dae04.
APA:
Gu, Hong,Sun, Erdan,Cui, Lei,Yang, Xiufen,Lim, Apiradee...&Liu, Ningpu.(2012).ASSOCIATION OF GLUTATHIONE S-TRANSFERASE PI ISOFORM SINGLE-NUCLEOTIDE POLYMORPHISMS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN A CHINESE POPULATION.RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES,32,(9)
MLA:
Gu, Hong,et al."ASSOCIATION OF GLUTATHIONE S-TRANSFERASE PI ISOFORM SINGLE-NUCLEOTIDE POLYMORPHISMS WITH EXUDATIVE AGE-RELATED MACULAR DEGENERATION IN A CHINESE POPULATION".RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES 32..9(2012):1967-1972