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Combined p53-related genetic variants together with HPV infection increase oral cancer risk

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收录情况： ◇ SCIE

作者：
Wang, Zhongqiu[1,2] * ; Sturgis, Erich M.[1,3] ; Zhang, Yang[1,4] ; Huang, Zhigang[1,4] ; Zhou, Qi[1,5] ; Wei, Qingyi[3] ; Li, Guojun[1,3,*1] ;
机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX [2]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China [3]Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX [4]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China [5]Department of Tumor Biological Treatment, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu, China
出处：
DOI： 10.1002/ijc.27335
ISSN：

关键词： p53 p73 MDM2 MDM4 HPV infection oral cancer

摘要：
To explore the role of polymorphisms of p53-related genes in etiology of oral cancer, we investigated joint effects of seven putatively functional polymorphisms of p53 (codon 72 Arg/Pro), p73 (4/14 GC/AT), murine double minute 2 gene (MDM2; A2164G and T2580G) and MDM4 (rs11801299 G > A, rs10900598 G > T and rs1380576 C > G) on risk of human papillomavirus (HPV)16-associated oral cancer in a casecontrol study with 325 cases and 335 cancer-free controls. We found that HPV16 seropositivity alone was associated with an increased risk of oral cancer [adjusted odds ratio (OR), 3.1; 95% confidence interval (CI), 2.14.6]. After combining genotypes of seven polymorphisms and using the low-risk group (03 combined risk genotypes) and HPV16 seronegativity as the reference group, the medium-risk (4 combined risk genotypes) and high-risk groups (57 combined risk genotypes) and HPV16 seronegativity were associated with only an OR of 1.6 (95% CI, 1.12.5) and 1.2 (95% CI, 0.71.9) for oral cancer risk, respectively, whereas the low-risk, medium-risk and high-risk groups and HPV16 seropositivity were significantly associated with a higher OR of 2.1 (95% CI, 1.23.6), 4.0 (95% CI, 1.89.1) and 19.1 (95% CI, 5.764.2), respectively. Notably, such effect modification by these combined risk genotypes was particularly pronounced in young subjects (aged < 50 years), never smokers and patients with oropharyngeal cancer. Taken together, these findings suggest that the combined risk genotypes of p53-related genes may modify risk of HPV16-associated oral cancer, especially in young patients, never-smokers and patients with oropharyngeal cancer. Larger studies are needed to validate our findings.

基金：
National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 ES-11740, CA-131274, CA-135679, CA-133099]; American Laryngological, Rhinological, and Otological Society; U.T. M.D. Anderson Cancer Center; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Cancer Institute (NCI) [R01CA131274, R03CA135679, K07CA133099] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Environmental Health Sciences (NIEHS) [R01ES011740] Funding Source: NIH RePORTER
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外文
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出版当年[2011]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2010]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2010版] 出版当年五年平均 出版前一年[2009版] 出版后一年[2011版]

第一作者：
第一作者机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX [2]Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, China
通讯作者：
通讯机构： [1]Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX [3]Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, TX [*1]Univ Texas MD Anderson Canc Ctr, Dept Head & Neck Surg, Unit 1445, 1515 Holcombe Blvd, Houston, TX 77030 USA
推荐引用方式(GB/T 7714)：
Wang Zhongqiu,Sturgis Erich M.,Zhang Yang,et al.Combined p53-related genetic variants together with HPV infection increase oral cancer risk[J].INTERNATIONAL JOURNAL OF CANCER.2012,131(3):E251-E258.doi:10.1002/ijc.27335.
APA：
Wang, Zhongqiu,Sturgis, Erich M.,Zhang, Yang,Huang, Zhigang,Zhou, Qi...&Li, Guojun.(2012).Combined p53-related genetic variants together with HPV infection increase oral cancer risk.INTERNATIONAL JOURNAL OF CANCER,131,(3)
MLA：
Wang, Zhongqiu,et al."Combined p53-related genetic variants together with HPV infection increase oral cancer risk".INTERNATIONAL JOURNAL OF CANCER 131..3(2012):E251-E258

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