Purpose: To examine the effect of intraocularly produced glucagon-like peptide-1 (GLP-1) on the survival rate of retinal ganglion cells in the optic nerve crush model.
Methods : Forty-one Sprague-Dawley rats were divided into a study group (21 animals) in which 4 beads with 3000 genetically modified cells to produce GLP-1 were intravitreally implanted into the right eye; a saline control group (n=12) with intravitreal saline injection into the right eye; and a GLP-1 negative bead control group (n=8) in which 4 beads with 3000 cells without GLP-1 production were intravitreally implanted into the right eye. The right optic nerves of all animals were crushed in a standardized manner. After labeling the retinal ganglion cells by injecting 3% fluorogold into the superior colliculus, the animals were sacrificed, and the ganglion cells were counted on retinal flat mounts.
第一作者机构：[1]Fac Clin Med Mannheim Heidelberg, Ophthalmol, Mannheim, Germany
推荐引用方式(GB/T 7714)：
Jonas J. B.,Zhang R.,Zhang H.,et al.Neuroprotective Effect of Intravitreal Cell-Based Glucagon-Like Peptide-1 Production in the Optic Nerve Crush Model[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2010,51(13):
APA：
Jonas, J. B.,Zhang, R.,Zhang, H.,Xu, L.,Ma, K.&Wallrapp, C..(2010).Neuroprotective Effect of Intravitreal Cell-Based Glucagon-Like Peptide-1 Production in the Optic Nerve Crush Model.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,51,(13)
MLA：
Jonas, J. B.,et al."Neuroprotective Effect of Intravitreal Cell-Based Glucagon-Like Peptide-1 Production in the Optic Nerve Crush Model".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 51..13(2010)
医学