Purpose:According to Quigley's hypothesis the dense of connective tissue is the least and the pores of the lamina cribrosa are the largest at the superior and infe rior poles of the lamina cribrosa,therefore they are the most vulnerable location to be involved in the characteristic glaucomatous optic nerve damage.To get clin-ical evidence for thehypothesis,the reversal of optic cup in adults glaucoma after reduction of intraocular pressure(IOP) was examined.Methods:The stereoscopic flicker comparison on with computerized image sys-tem was used to monitor the optic cup's changing,2 serial superposed stereo pairs were displayed alternatively and rapidly and the changing parts appeared moving Under the stereoscopic observation,the changes of 3-dimention optic cup could be seen and the false positive phenomena caused by photographic angle variation,vascular pulsation could be differentiated from the characteristic change of the cup.Stereo fundus photographs were taken from 31 eyes with hy-pertension glaucoma before and after treatment of reduction of IOPs which was either diamox administration or trabeculectomy.Results:the result showed that the reversal of optic cups after reduction of IOPs were mostly asymmetrical,especially at the inferior and/or superior poles.By multiple stepwise regression,it is known that the amount of the change is only correlated with the initial elevated IOP.Conclusions:The study indicated that it was the distortion and deformity of the lamina cribrosa leading to shearing stress that results in glaucomatous character-istic damage in structure and function.The individul tolerance of the lamina cribrosa to the high intraocular pressure and the locations of individual vulnerable at he optic nerve head are various.