机构：[1]Beijing TongRen Eye Center, Beijing Tongren Hospital, Vision Science Laboratory, School of Ophthalmology,Capital Medical University, Beijing 100730, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology, No. 4 Hospital of XI’an, #21 JieFang Road, XI’an 710004, China[3]Department of Neurobiology, Beijing Key Laboratory for Neural Regeneration and Repairing,Institute for Biomedical Science of Pain, Capital Medical University, Beijing 100069, China
In our previous study, we found the increased expression of p75(NTR) and sortilin by Western blotting in ischemic retina induced by elevated intraocular pressure (IOP). Cell specific expression of sortilin and p75 neurotrophin receptor (p75(NTR)) was now characterized in normal and ischemic rat retina induced by elevated (IOP) by double-labeling immunochemistry. Two patterns of sortilin staining in normal retina were identified: punctate and consistent. The former was seen in the retinal ganglion cell (RGC) bodies, probably in Golgi apparatus. The latter was found in astrocytes and Muller glial cells (MGCs). The expression pattern of sortilin did not change in ischemic state induced by elevated IOP. p75(NTR) was not found in RGCs, but in MGCs of most of the retinal layers, especially the inner plexiform layer (IPL), and outer plexiform layer (OPL) of normal retina. Taken together, the enhanced expression of sortilin in MGCs might be involved in the neuro-glial interactions in ischemic retina, but may not directly contribute to RGCs death through proNGF binding to complex receptor composed of sortilin and p75(NTR) in ischemic retina. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30672283, 30571991]
第一作者机构：[1]Beijing TongRen Eye Center, Beijing Tongren Hospital, Vision Science Laboratory, School of Ophthalmology,Capital Medical University, Beijing 100730, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Fenfen,Wei Yong,Lu Qingjun,et al.Immunohistochemical localization of sortilin and p75(NTR) in normal and ischemic rat retina[J].NEUROSCIENCE LETTERS.2009,454(1):81-85.doi:10.1016/j.neulet.2009.02.036.
APA：
Xu, Fenfen,Wei, Yong,Lu, Qingjun,Zheng, Deyu,Zhang, Fukang...&Wang, Ningli.(2009).Immunohistochemical localization of sortilin and p75(NTR) in normal and ischemic rat retina.NEUROSCIENCE LETTERS,454,(1)
MLA：
Xu, Fenfen,et al."Immunohistochemical localization of sortilin and p75(NTR) in normal and ischemic rat retina".NEUROSCIENCE LETTERS 454..1(2009):81-85
