Background: The aim was to determine the prevalence of retinal lesions in patients infected by the human immunodeficiency virus (HIV) in China. Methods: The study included 105 consecutive patients with an HIV infection that underwent general and ophthalmologic examinations. In none of the patients was any systemic opportunistic infection found. The CD4+ T lymphocyte count determined in 89 patients revealed that 77 patients (87%) had a CD4+ lymphocyte count of > 200 x 10(6)/l. Results: Retinal microvascular abnormalities were found in 12 subjects (11%) and local retinal nerve fiber layer defects in 13 patients (12%). Patients with fundus abnormalities compared to those with a normal fundus had a significantly (p = 0.013) lower CD4+ T cell count (166 +/- 67) x 10(6)/l vs. 482 +/- 33 x 10(6)/l) and did not vary significantly in visual acuity. Conclusions: In these HIV- positive Chinese patients attending a hospital for infectious diseases, retinal microvasculopathy and retinal nerve fiber layer defects were the most common fundus lesions, which were found in about 10% of the patients and which were inversely associated with the CD4+ T cell count, without marked effect on visual acuity. Copyright (C) 2008 S. Karger AG, Basel.
基金：
Beijing Municipal Science and Technology Commission, Beijing, China (Beijing Natural Science Fund for ‘The study on AIDS surveillance, screening, prevention and control strategy among high-risk behaviour population in Beijing.’
Fund No.: D0906003040591).
第一作者机构：[1]Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China
通讯作者：
通讯机构：[1]Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, Beijing 100005, Peoples R China[3]Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany[*1]Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Inst Ophthalmol, 17 Hougou St Chong Wen Men, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Wang Jian,You Qisheng,Yang Hua,et al.Retinal findings in Chinese patients with HIV infection[J].OPHTHALMIC RESEARCH.2008,40(2):98-100.doi:10.1159/000113888.
APA：
Wang, Jian,You, Qisheng,Yang, Hua,Li, Haiying,Wu, Hao...&Jonas, Jost B..(2008).Retinal findings in Chinese patients with HIV infection.OPHTHALMIC RESEARCH,40,(2)
MLA：
Wang, Jian,et al."Retinal findings in Chinese patients with HIV infection".OPHTHALMIC RESEARCH 40..2(2008):98-100
