机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China[2]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, PR China[3]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China[4]Shenzhen Key Laboratory of Neurosurgery, Department of Neurosurgery Shenzhen Second People’s Hospital, Shenzhen University 1st Affiliated Hospital, Shenzhen 518035, PR China深圳市第二人民医院深圳市康宁医院深圳医学信息中心[5]Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, PR China北京朝阳医院[6]Beijing Key Laboratory of Ionic Liquids Clean Process, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China[7]State Key Laboratory of Multiphase Complex Systems, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China[8]Medical School of Chinese PLA, Beijing 100853, PR China
Reactive oxygen species (ROS) are key contributors to inflammatory progression and damage. Upon clinical and experimental observation of vascular abnormalities in acute inflammatory diseases, we explore cellular vesicles as templates and carriers to elevate therapeutic performance of nano-antioxidant. Specifically, we develop a mild one-pot approach for in situ growth of cerium oxide (Ce) nanocrystals onto nano-sized red blood cells vesicles (ReVs). Besides excellent biocompatibility, Ce-ReVs have very high ROS-scavenging activity, which is experimentally and theoretically explained by discovering the unique functions of membrane lipids in optimizing Ce nanocrystals with ultrasmall size (similar to 3 nm) and ultrahigh Ce(III) content (similar to 60.8%). In colitis and acute liver injury models, Ce-ReVs notably enhance accumulation at the inflamed sites and confer strong ROS elimination. Moreover, we upgrade the system by hybridizing ReVs with mesenchymal stem cell-derived exosomes and demonstrate additional repair function of highly damaged tissues, further verifying the satisfactory flexibility and therapeutic efficacy. (C) 2021 The Author(s). Published by Elsevier Ltd.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81871912, 81970530, 21821005, 32030062, U2001224]; Shanghai Municipal Health Bureau Key Disciplines Grant [ZK2019C012]; National Science and Technology Major Project of China [2018ZX10301-103-003]
第一作者机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China[2]Department of Gastroenterology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, PR China
共同第一作者：
通讯作者：
通讯机构：[1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China[3]School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China[*1]State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, PR China.
推荐引用方式(GB/T 7714)：
Zhao Jiawei,Wang Yugang,Wang Wenjing,et al.In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases[J].NANO TODAY.2021,40:doi:10.1016/j.nantod.2021.101282.
APA：
Zhao, Jiawei,Wang, Yugang,Wang, Wenjing,Tian, Ying,Gan, Zhongdong...&Ma, Guanghui.(2021).In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases.NANO TODAY,40,
MLA：
Zhao, Jiawei,et al."In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases".NANO TODAY 40.(2021)
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工程技术