机构：[1]Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[2]Department of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medical CSU, Hunan, China,[3]Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China,[4]Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China,[5]University of Chinese Academy of Sciences, Beijing, China
The goal of a biomaterial is to support the bone tissue regeneration process at the defect site and eventually degrade in situ and get replaced with the newly generated bone tissue. Biomaterials that enhance bone regeneration have a wealth of potential clinical applications from the treatment of non-union fractures to spinal fusion. The use of bone regenerative biomaterials from bioceramics and polymeric components to support bone cell and tissue growth is a longstanding area of interest. Recently, various forms of bone repair materials such as hydrogel, nanofiber scaffolds, and 3D printing composite scaffolds are emerging. Current challenges include the engineering of biomaterials that can match both the mechanical and biological context of bone tissue matrix and support the vascularization of large tissue constructs. Biomaterials with new levels of biofunctionality that attempt to recreate nanoscale topographical, biofactor, and gene delivery cues from the extracellular environment are emerging as interesting candidate bone regenerative biomaterials. This review has been sculptured around a case-by-case basis of current research that is being undertaken in the field of bone regeneration engineering. We will highlight the current progress in the development of physicochemical properties and applications of bone defect repair materials and their perspectives in bone regeneration.
基金：
National Natural Science
Foundation of China (51973226 and 81871782), the National
Science Foundation for Postdoctoral Scientists of China
(2020M683733), the Shanghai Changning Committee of Science
and Technology of China (CNKW2020Y01), and the Youth
Innovation Promotion Association CAS (2019031).
第一作者机构：[1]Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[2]Department of Spine Surgery, The Affiliated Zhuzhou Hospital of Xiangya School of Medical CSU, Hunan, China,[3]Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Orthopedic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China,[3]Department of Orthopedic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China,[4]Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China,[5]University of Chinese Academy of Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Tang Guoke,Liu Zhiqin,Liu Yi,et al.Recent Trends in the Development of Bone Regenerative Biomaterials[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2021,9:doi:10.3389/fcell.2021.665813.
APA：
Tang, Guoke,Liu, Zhiqin,Liu, Yi,Yu, Jiangming,Wang, Xing...&Ye, Xiaojian.(2021).Recent Trends in the Development of Bone Regenerative Biomaterials.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9,
MLA：
Tang, Guoke,et al."Recent Trends in the Development of Bone Regenerative Biomaterials".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9.(2021)
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