Mucin 1 (MUC1) is a heterodimeric transmembrane glycoprotein that protects epithelial cells in mammals. The transmembrane C-terminal subunit (MUC1-C) plays a crucial role in oncogenesis. As an oncoprotein, MUC1-C regulates a number of proteins that are associated with tumorigenesis by interacting with oncoproteins, transcription factors, coactivators, etc., inducing proliferation, epithelial-mesenchymal transition (EMT), invasion, stemness, immune evasion, and drug resistance. Moreover, MUC1-C modulates the expression of non-coding RNAs (ncRNAs), which further regulate carcinogenesis by directly binding to specific proteins. ncRNAs can also affect MUC1 protein expression by targeting the MUC1 mRNA 3 ' untranslated region (UTR). A series of ncRNAs can modulate cancer development by regulating MUC1-C. This review focuses on the interaction of MUC1-C with proteins and ncRNAs in cancer progression. We also summarize the recent advances in immunotherapy with a focus on therapeutic approaches based on MUC1-C and nanocarrier complexes for cancer treatment.
基金：
National Natural Science Foundation of China [81602469]; Shanghai Natural Science Foundation [20ZR1443000]; Excellent Youth Foundation of Tongji University [.2016KJ045]; Foundation of Pujiang Talents Plan [20PJ1412400]
第一作者机构：[1]Tongji Univ, Shanghai Tenth Peoples Hosp, Dept Urol, Shanghai, Peoples R China[2]Tongji Univ, Urol Canc Inst, Sch Med, Shanghai, Peoples R China[*1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road,Jing'an District, Shanghai, 200072 China.
共同第一作者：
通讯作者：
通讯机构：[1]Tongji Univ, Shanghai Tenth Peoples Hosp, Dept Urol, Shanghai, Peoples R China[2]Tongji Univ, Urol Canc Inst, Sch Med, Shanghai, Peoples R China[7]Harvard Med Sch, Dana Farber Canc Inst, Boston, MA 02115 USA[*1]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road,Jing'an District, Shanghai, 200072 China.[*2]Department of Urology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, No.301 Yanchang Road, Jing'an District, Shanghai, 200072 China.[*3]Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, D830, Boston, Massachusetts, USA
推荐引用方式(GB/T 7714)：
Li Wei,Han Yineng,Sun Chenmin,et al.Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating and RNAs in cancer[J].THERANOSTICS.2022,12(3):999-1011.doi:10.7150/thno.63654.
APA：
Li, Wei,Han, Yineng,Sun, Chenmin,Li, Xue,Zheng, Junhua...&Kufe, Donald.(2022).Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating and RNAs in cancer.THERANOSTICS,12,(3)
MLA：
Li, Wei,et al."Novel insights into the roles and therapeutic implications of MUC1 oncoprotein via regulating and RNAs in cancer".THERANOSTICS 12..3(2022):999-1011
医学