MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling
Hypertension is the leading risk factor for cardiovascular disorders. This study aimed to explore roles of microRNA (miR)-122-5p in hypertension. Angiotensin II (Ang II; 1.5 mg/kg/day) with an osmotic minipump was used to induce hypertensive rats pretreated by rAAV-miR-122-5p or rAAV-GFP, respectively. Notably, Ang II infusion caused marked increases in myocardial fibrosis, inflammation, oncosis, and oxidant injury in rats, which were aggravated by rAAV-miR-122-5p. RAAV-miR-122-5p exacerbated Ang II-mediated cardiac dysfunction and structural injury in hypertensive rats, with downregulated levels of apelin, elabela, ACE2, and GDF15, as well as upregulated expression of porimin and CTGF. In cultured rat cardiac fibroblasts, Ang II contributed to augmentation of cellular oncosis, migration, inflammation, and oxidative stress, with reduction of apelin, elabela, ACE2, and GDF15 levels, which were rescued by miR-122 inhibitor. In summary, miR-122-5p exacerbates myocardial fibrosis and dysfunction in hypertensive rats by modulating the elabela/apelin-ACE2-GDF15 signaling. MiR-122-5p has potential therapeutic significance for hypertension and hypertensive cardiac injury.
基金：
National Natural Science Foundation of China [92168117, 81770253, 91849111, 81370362]; Natural Science Foundation of Beijing [7222068]; Shanghai Sailing Program [20YF1444100]; Beijing Postdoctoral Research Foundation
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类|3 区医学
小类|3 区心脏和心血管系统3 区医学：研究与实验
最新[2025]版：
大类|4 区医学
小类|4 区心脏和心血管系统4 区医学：研究与实验
JCR分区：
出版当年[2020]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ2MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2CARDIAC & CARDIOVASCULAR SYSTEMSQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Capital Med Univ, Beijing Chaoyang Hosp, Heart Ctr, Beijing, Peoples R China[2]Capital Med Univ, Beijing Chaoyang Hosp, Beijing Key Lab Hypertens, Beijing, Peoples R China[3]Capital Med Univ, Beijing Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China[4]Capital Med Univ, Beijing Inst Resp Med, Med Res Ctr, Beijing, Peoples R China[5]Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Chaoyang Hosp, Heart Ctr, Beijing, Peoples R China[2]Capital Med Univ, Beijing Chaoyang Hosp, Beijing Key Lab Hypertens, Beijing, Peoples R China[3]Capital Med Univ, Beijing Chaoyang Hosp, Dept Cardiol, Beijing, Peoples R China[4]Capital Med Univ, Beijing Inst Resp Med, Med Res Ctr, Beijing, Peoples R China[5]Capital Med Univ, Beijing Chaoyang Hosp, Beijing, Peoples R China[6]Shanghai Jiao Tong Univ, Dept Psychiat, Hypertens Ruijin Hosp, Shanghai Inst, Shanghai, Peoples R China[7]Shanghai Jiao Tong Univ, Sch Med, Hypertens Ruijin Hosp, Shanghai Inst, Shanghai, Peoples R China
推荐引用方式(GB/T 7714)：
Song Jiawei,Zhang Zhenzhou,Dong Zhaojie,et al.MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling[J].JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH.2022,15(3):535-547.doi:10.1007/s12265-022-10214-3.
APA：
Song, Jiawei,Zhang, Zhenzhou,Dong, Zhaojie,Liu, Xinming,Liu, Ying...&Zhong, Jiuchang.(2022).MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling.JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH,15,(3)
MLA：
Song, Jiawei,et al."MicroRNA-122-5p Aggravates Angiotensin II-Mediated Myocardial Fibrosis and Dysfunction in Hypertensive Rats by Regulating the Elabela/Apelin-APJ and ACE2-GDF15-Porimin Signaling".JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 15..3(2022):535-547
