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DcardNet: Diabetic Retinopathy Classification at Multiple Levels Based on Structural and Angiographic Optical Coherence Tomography

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机构: [1]Casey Eye Institute, Oregon Health & Science University [2]Department of Biomedical Engineering, Oregon Health & Science University. [3]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University. [4]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239 USA [5]Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA
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关键词: Faces Retina Retinopathy Diabetes Feature extraction Smoothing methods Reflectivity Eye image classification neural networks optical coherence tomography

摘要:
Objective: Optical coherence tomography (OCT) and its angiography (OCTA) have several advantages for the early detection and diagnosis of diabetic retinopathy (DR). However, automated, complete DR classification frameworks based on both OCT and OCTA data have not been proposed. In this study, a convolutional neural network (CNN) based method is proposed to fulfill a DR classification framework using en face OCT and OCTA. Methods: A densely and continuously connected neural network with adaptive rate dropout (DcardNet) is designed for the DR classification. In addition, adaptive label smoothing was proposed and used to suppress overfitting. Three separate classification levels are generated for each case based on the International Clinical Diabetic Retinopathy scale. At the highest level the network classifies scans as referable or non-referable for DR. The second level classifies the eye as non-DR, non-proliferative DR (NPDR), or proliferative DR (PDR). The last level classifies the case as no DR, mild and moderate NPDR, severe NPDR, and PDR. Results: We used 10-fold cross-validation with 10% of the data to assess the network's performance. The overall classification accuracies of the three levels were 95.7%, 85.0%, and 71.0% respectively. Conclusion/Significance: A reliable, sensitive and specific automated classification framework for referral to an ophthalmologist can be a key technology for reducing vision loss related to DR.

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出版当年[2020]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学
最新[2023]版:
大类 | 2 区 医学
小类 | 2 区 工程:生物医学
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出版当年[2019]版:
Q1 ENGINEERING, BIOMEDICAL
最新[2023]版:
Q2 ENGINEERING, BIOMEDICAL

影响因子: 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

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第一作者机构: [1]Casey Eye Institute, Oregon Health & Science University [2]Department of Biomedical Engineering, Oregon Health & Science University.
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通讯机构: [4]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239 USA [5]Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA
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