机构:[1]Casey Eye Institute, Oregon Health & Science University[2]Department of Biomedical Engineering, Oregon Health & Science University.[3]Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University.首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239 USA[5]Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA
Objective: Optical coherence tomography (OCT) and its angiography (OCTA) have several advantages for the early detection and diagnosis of diabetic retinopathy (DR). However, automated, complete DR classification frameworks based on both OCT and OCTA data have not been proposed. In this study, a convolutional neural network (CNN) based method is proposed to fulfill a DR classification framework using en face OCT and OCTA. Methods: A densely and continuously connected neural network with adaptive rate dropout (DcardNet) is designed for the DR classification. In addition, adaptive label smoothing was proposed and used to suppress overfitting. Three separate classification levels are generated for each case based on the International Clinical Diabetic Retinopathy scale. At the highest level the network classifies scans as referable or non-referable for DR. The second level classifies the eye as non-DR, non-proliferative DR (NPDR), or proliferative DR (PDR). The last level classifies the case as no DR, mild and moderate NPDR, severe NPDR, and PDR. Results: We used 10-fold cross-validation with 10% of the data to assess the network's performance. The overall classification accuracies of the three levels were 95.7%, 85.0%, and 71.0% respectively. Conclusion/Significance: A reliable, sensitive and specific automated classification framework for referral to an ophthalmologist can be a key technology for reducing vision loss related to DR.
基金:
This work
was supported in part by the National Institutes of Health (Bethesda,
MD) under Grants R01 EY027833, R01 EY024544, and P30 EY010572,
and in part by an unrestricted departmental funding grant and William &
Mary Greve Special Scholar Award from Research to Prevent Blindness
(New York, NY).
第一作者机构:[1]Casey Eye Institute, Oregon Health & Science University[2]Department of Biomedical Engineering, Oregon Health & Science University.
通讯作者:
通讯机构:[4]Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239 USA[5]Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239 USA
推荐引用方式(GB/T 7714):
Zang Pengxiao,Gao Liqin,Hormel Tristan T.,et al.DcardNet: Diabetic Retinopathy Classification at Multiple Levels Based on Structural and Angiographic Optical Coherence Tomography[J].IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING.2021,68(6):1859-1870.doi:10.1109/TBME.2020.3027231.
APA:
Zang, Pengxiao,Gao, Liqin,Hormel, Tristan T.,Wang, Jie,You, Qisheng...&Jia, Yali.(2021).DcardNet: Diabetic Retinopathy Classification at Multiple Levels Based on Structural and Angiographic Optical Coherence Tomography.IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING,68,(6)
MLA:
Zang, Pengxiao,et al."DcardNet: Diabetic Retinopathy Classification at Multiple Levels Based on Structural and Angiographic Optical Coherence Tomography".IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 68..6(2021):1859-1870