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Trends in the biological functions and medical applications of extracellular vesicles and analogues

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 统计源期刊 ◇ CSCD-C ◇ 卓越：领军期刊

作者：
Zhao, Yan[1,2] * ; Li, Xiaolu[2] * ; Zhang, Wenbo[2] * ; Yu, Lanlan[2] * ; Wang, Yang[2] ; Deng, Zhun[2] ; Liu, Mingwei[2] ; Mo, Shanshan[2] ; Wang, Ruonan[2] ; Zhao, Jinming[1] ; Liu, Shuli[4] ; Hao, Yun[1] ; Wang, Xiangdong[1] ; Ji, Tianjiao[3,6] ; Zhang, Luo[1,5] ; Wang, Chenxuan[2] ;
机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China [2]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China [3]CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China [4]Department of Clinical Laboratory, Peking University Civil Aviation School of Clinical Medicine, Beijing 100123, China [5]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China [6]Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
出处：
DOI： 10.1016/j.apsb.2021.03.012
ISSN：

关键词： Extracellular vesicles Exosomes Biomarkers Intercellular communications Drug delivery

摘要：
Natural extracellular vesicles (EVs) play important roles in many life processes such as in the intermolecular transfer of substances and genetic information exchanges. Investigating the origins and working mechanisms of natural EVs may provide an understanding of life activities, especially regarding the occurrence and development of diseases. Additionally, due to their vesicular structure, EVs (in small molecules, nucleic acids, proteins, etc.) could act as efficient drug-delivery carriers. Herein, we describe the sources and biological functions of various EVs, summarize the roles of EVs in disease diagnosis and treatment, and review the application of EVs as drug-delivery carriers. We also assess the challenges and perspectives of EVs in biomedical applications. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31901007, 81630023, 81970852, 82000962]; CAMS Innovation Fund for Medical Sciences, China (China) [2018-I2M-3-006, 2019-I2M-5-022]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020T130006ZX]; Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS (China) [NSKF202019]; State Key Laboratory Special Fund [2060204]; National Key R&D Program of China [2016YFC0905200]; Changjiang scholars and innovative research team (China) [IRT13082]; Beijing Bai-Qian-Wan talent project (China) [2019A32]; Public Welfare Development and Reform Pilot Project (China) [2019-10]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 医学
小类 | 1 区 药学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 药学
JCR分区：
出版当年[2019]版：
Q1 PHARMACOLOGY & PHARMACY
最新[2023]版：
Q1 PHARMACOLOGY & PHARMACY

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China [2]State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China [3]CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China [5]Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China [6]Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China
推荐引用方式(GB/T 7714)：
Zhao Yan,Li Xiaolu,Zhang Wenbo,et al.Trends in the biological functions and medical applications of extracellular vesicles and analogues[J].ACTA PHARMACEUTICA SINICA B.2021,11(8):2114-2135.doi:10.1016/j.apsb.2021.03.012.
APA：
Zhao, Yan,Li, Xiaolu,Zhang, Wenbo,Yu, Lanlan,Wang, Yang...&Wang, Chenxuan.(2021).Trends in the biological functions and medical applications of extracellular vesicles and analogues.ACTA PHARMACEUTICA SINICA B,11,(8)
MLA：
Zhao, Yan,et al."Trends in the biological functions and medical applications of extracellular vesicles and analogues".ACTA PHARMACEUTICA SINICA B 11..8(2021):2114-2135

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