机构：[1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China[2]College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China[3]Department of Laboratory Animal Sciences, Capital Medical University, Beijing, China[4]Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University & Beijing Institute of Respiratory Medicine, Beijing, China北京朝阳医院[5]Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing, China临床科室耳鼻咽喉-头颈外科研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[6]Division of Asthma, Allergy & Lung Biology, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, King’s College London, London, UK
While environmental aeroallergens and epithelial alarmins such as IL-33 are firmly implicated in asthma, the possible role of Streptococcus pneumoniae (S. pneumoniae) antigens is less clear. To explore this, wild-type BALB/c mice were repeatedly challenged per-nasally with IL-33 and inactivated S. pneumoniae, either agent alone or diluent control. Some animals were rested then later re-challenged with inactivated S. pneumoniae alone. Serum concentrations of S. pneumoniae lysates-specific IgE were measured in patients with asthma and control subjects. Interestingly, in the presence of IL-33, repeated exposure to inactivated S. pneumoniae induced asthma-like pathological changes accompanied by a systemic adaptive immune response. Subsequent re-exposure of the sensitized animals to inactivated S. pneumoniae alone was able to induce such changes. The concentration of S. pneumoniae lysates-specific IgE was significantly elevated in the asthma patients. These data suggest that antigens derived from infectious microorganisms may participate in generating the mucosal inflammation which characterizes asthma.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [82071805, 81700026, 81971510]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7192023]; Support Project of High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan [IDHT20190510]
第一作者机构：[1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China[2]College of Integrated Chinese and Western Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
通讯作者：
通讯机构：[1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, Beijing, China[*1]Department of Immunology, School of Basic Medical Sciences, Capital Medical University, 10# Xi Tou Tiao, You An Men Wai, Fengtai District, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Li Chenduo,Du Xiaonan,Huang Qiong,et al.Repeated exposure to inactivated Streptococcus pneumoniae induces asthma-like pathological changes in mice in the presence of IL-33[J].CELLULAR IMMUNOLOGY.2021,369:doi:10.1016/j.cellimm.2021.104438.
APA：
Li, Chenduo,Du, Xiaonan,Huang, Qiong,Yang, Yiran,Wang, Jingjing...&Ying, Sun.(2021).Repeated exposure to inactivated Streptococcus pneumoniae induces asthma-like pathological changes in mice in the presence of IL-33.CELLULAR IMMUNOLOGY,369,
MLA：
Li, Chenduo,et al."Repeated exposure to inactivated Streptococcus pneumoniae induces asthma-like pathological changes in mice in the presence of IL-33".CELLULAR IMMUNOLOGY 369.(2021)
