机构：[1]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[2]Spleen and Stomach Department, Jiyang District Hospital of Traditional Chinese Medicine, Jinan, Shandong 251400, China[3]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
In recent years, many cancer treatment strategies, such as photothermal therapy (PTT), have played a crucial role in confronting the major bottleneck of gastric cancer variability and complexity. However, it is still a challenge to effectively prolong the residence time of drugs in the tumor region to achieve a therapeutic effect on gastric cancer. Here, we fabricated innovative, intelligent, multifunctional core@shell magnetic nanoprobes with active targeting and real-time image-guided PTT capabilities. Superparamagnetic Mn@Co magnetic nanoparticles were synthesized using a seed growth strategy. After the process of amphiphilic polymer coating, chemical covalent coupling, and physical loading of drugs, the final PMA/Mn@Co-S-S-BSA@ICG-FA nanoprobes were successfully constructed for MRI/NIR imaging and PTT treatment of MGC-803 tumor-bearing mice in the presence of 808 nm laser irradiation. Benefiting from their good biocompatibility and long-term stability, the synthesized nanoprobes exhibited good tumor-targeting capability and photothermal therapeutic efficacy to inhibit gastric tumor growth in mice under 808 nm laser irradiation. The strategy presented in our study offers controllable delivery and release of distinctly targeted indocyanine green (ICG) and outstanding tumor inhibiting efficacy of PTT, creating a promising avenue for effective cancer treatment.
基金：
Project of National Key Research and Development Program of China [2017FYA0205301]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81903169]; Shanghai Sailing Program [19YF1422300]; SJTU "Transformation Medicine Cross Research Fund" [ZH2018QNB25, ZH2018QNB26]; Shanghai Tongren Hospital [2019shtrxx09]; International Cooperation and Exchanges NSFC [82020108017]
第一作者机构：[1]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China[3]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China[*1]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China[*2]Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China[*3]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, China
推荐引用方式(GB/T 7714)：
Deng Zhoufeng,Qiao Guanglei,Ma Lijun,et al.Photosensitizer-Functionalized Mn@Co Magnetic Nanoparticles for MRI/NIR-Mediated Photothermal Therapy of Gastric Cancer[J].ACS APPLIED NANO MATERIALS.2021,4(12):13523-13533.doi:10.1021/acsanm.1c02929.
APA：
Deng, Zhoufeng,Qiao, Guanglei,Ma, Lijun,Zhang, Qian,Zhang, Ping&Cui, Daxiang.(2021).Photosensitizer-Functionalized Mn@Co Magnetic Nanoparticles for MRI/NIR-Mediated Photothermal Therapy of Gastric Cancer.ACS APPLIED NANO MATERIALS,4,(12)
MLA：
Deng, Zhoufeng,et al."Photosensitizer-Functionalized Mn@Co Magnetic Nanoparticles for MRI/NIR-Mediated Photothermal Therapy of Gastric Cancer".ACS APPLIED NANO MATERIALS 4..12(2021):13523-13533
