Bone regeneration of critical-sized bone defects (CSBDs) with biomimetic collagen-based aerogels remains a significant challenge due to the oxidative stress on the microenvironment. The excessive oxidative stress could induce apoptosis and dysfunction of host-derived cells. Astaxanthin (ATX) exhibits excellent antioxidant ability to block free radical chain reactions. In the present study, hybrid antioxidant collagen-derived aerogels (ATX-Col aerogels) were fabricated by a simple one-step method through the covalent cross-linking of Col and ATX. The resulting ATX-Col aerogels show porous and interconnected structures due to freeze-drying strategies. The ATX-Col aerogels exhibited excellent biocompatibility and biosafety. Furthermore, ATX-Col aerogels demonstrated favorable antioxidant capacity by eliminating intracellular ROS by activating the NRF2 signaling pathway. Finally, excellent reparative effects in repairing rat cranial defects were observed in ATX-Col aerogels. Taken together, ATX-Col aerogels can accelerate bone regeneration by relieving oxidative stress via the NRF2 signaling pathway and act as a potential bone graft for CSBD. This study provides a simple method of developing antioxidant aerogels for bone regeneration.
基金：
National Natural Science Foundation of China [81772094,81974289, 81901981]; Key Research and Development Program of Hubei Province [2020BCB031]
第一作者机构：[1]Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Hand Surg, Wuhan 430022, Peoples R China
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推荐引用方式(GB/T 7714)：
Guo Jiahe,Yang Xiaofan,Chen Jing,et al.Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway[J].ACS BIOMATERIALS SCIENCE & ENGINEERING.2022,doi:10.1021/acsbiomaterials.2c00596.
APA：
Guo, Jiahe,Yang, Xiaofan,Chen, Jing,Wang, Cheng,Kang, Yu...&Chen, Zhenbing.(2022).Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway.ACS BIOMATERIALS SCIENCE & ENGINEERING,,
MLA：
Guo, Jiahe,et al."Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway".ACS BIOMATERIALS SCIENCE & ENGINEERING .(2022)
