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SOCS3 Silencing Promotes Activation of Vocal Fold Fibroblasts via JAK2/STAT3 Signaling Pathway

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收录情况： ◇ SCIE

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机构： [1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education of China, 1 Dongjiaominxiang, 100730, Beijing, China.

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关键词： SOCS3 JAK2/STAT3 signaling pathway Vocal fold injury siRNA Fibroblast

摘要：

Suppressor of cytokine signaling 3 (SOCS3) is a negative regulatory protein that has been identified as a key inhibitory regulator of JAK/STAT signaling pathway. However, the mutual regulatory relationship between SOCS3 and JAK2/STAT3 signaling pathway after vocal fold injury remains unclear. In this study, we used small interfering RNA (siRNA) to investigate the mechanism of SOCS3 regulating of fibroblasts through JAK2/STAT3 signaling pathway after vocal fold injury. Our data shows that SOCS3 silencing promotes the transformation of normal vocal fold fibroblasts (VFFs) into an fibrotic phenotype and activates the JAK2/STAT3 signaling pathway. JAK2 silencing significantly inhibits the increase in type I collagen and α-smooth muscle actin (α-SMA) secretion in VFFs induced by TGF-β but has no significant effect on normal VFFs. The silencing of SOCS3 and JAK2 reverses the fibrotic phenotype of VFFs induced by SOCS3 silencing. Therefore, we suggest that SOCS3 can affect the activation of vocal fold fibroblasts by regulating the JAK2/STAT3 signaling pathway after vocal fold injury. It provides a new insight for promoting the repair of vocal fold injury and preventing the formation of fibrosis.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

基金：

基金编号： 82171124; 81870709.7212014

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出版当年[2022]版：

大类 | 2 区医学

小类 | 3 区免疫学 3 区细胞生物学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区细胞生物学 3 区免疫学

JCR分区：

出版当年[2021]版：

Q2 IMMUNOLOGY Q3 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 IMMUNOLOGY

影响因子： 4.5 最新[2023版] 4.6 最新五年平均 4.657 出版当年[2021版] 4.361 出版当年五年平均 4.092 出版前一年[2020版] 5.1 出版后一年[2022版]

第一作者：

第一作者机构： [1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education of China, 1 Dongjiaominxiang, 100730, Beijing, China.

通讯作者：

通讯机构： [1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education of China, 1 Dongjiaominxiang, 100730, Beijing, China. [*1]Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education of China, 1 Dongjiaominxiang, 100730, Beijing, China.

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