机构：[1]Institute of Allergology, Charité – Universitätsmedizin Berlin, FreieUniversität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany[2]University Hospital Montpellier, Montpellier, France[3]Fraunhofer Institute for Translational Medicine and Pharmacology ITMP,Allergology and Immunology, Berlin, Germany[4]National Heart and Lung Institute (NHLI), Imperial College London, London,UK[5]NIHR Imperial Biomedical Research Centre, London, UK[6]ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain[7]Universitat Pompeu Fabra (UPF), Barcelona, Spain[8]CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain[9]Department of Health Research Methods, Evidence, and Impact,Department of Medicine, McMaster University, Hamilton, Ontario, Canada[10]Department of Biomedical Sciences, Humanitas University, Milan, Italy[11]Personalized Medicine, Asthma & Allergy, IRCCS Humanitas ResearchCenter, Milan, Italy[12]Department of Clinical Immunology, Wrocław Medical University,Wroclaw, Poland[13]ALL-MED Medical Research Institute, Wroclaw, Poland[14]Department of Medical Sciences and Public Health and Unit of Allergyand Clinical Immunology, University Hospital "Duilio Casula," University ofCagliari, Cagliari, Italy[15]Section of Rhinology and Allergy, Department of Otorhinolaryngology,Head and Neck Surgery, University Hospital Marburg, Philipps-UniversitätMarburg, Marburg, Germany[16]MEDCIDS - Department of Community Medicine, Information and HealthDecision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal[17]CINTESIS@RISE– Health Research Network, Faculty of Medicine,University of Porto, Porto, Portugal[18]Department of Otolaryngology, Head and Neck Surgery,Universitätsmedizin Mainz, Mainz, Germany[19]Center for Rhinology and Allergology, Wiesbaden, Germany[20]Medical Consulting Czarlewski, Levallois, France[21]MASK-air, Montpellier, France[22]ARIA, Montpellier, France[23]Department of Allergy and Immunology, Hospital Quironsalud Bizkaia,Bilbao, Spain[24]Quality Use of Respiratory Medicines Group, Woolcock Institute ofMedical Research, Sydney, New South Wales, Australia[25]Sydney Local Health District, Sydney, New South Wales, Australia[26]Sydney Pharmacy School, The University of Sydney, Sydney, New SouthWales, Australia[27]Respiratory Clinic, Department of Internal Medicine, University of Genoa,Genoa, Italy[28]IRCCS Ospedale Policlinico San Martino, Genoa, Italy[29]Pneumology Unit, Hospitais da Universidade de Coimbra, CentroHospitalar e Universitário de Coimbra, Coimbra, Portugal[30]Department of Pulmonary Diseases, Istanbul University - Cerrahpaşa,Cerrahpaşa Faculty of Medicine, Istanbul, Turkey[31]Skin and Allergy Hospital, Helsinki University Hospital, University ofHelsinki, Helsinki, Finland[32]Department of Pediatric Respiratory Diseases and Allergology, MedicalUniversity of Warsaw, Warsaw, Poland[33]Division of Internal Medicine, Asthma and Allergy, Barlicki UniversityHospital, Medical University of Lodz, Lodz, Poland[34]Pediatric Pulmonology, Immunology and Intensive Care Medicine, CharitéUniversitätsmedizin Berlin, Berlin, Germany[35]Allergy and Clinical Immunology Unit, Centro Hospitalar e Universitário deCoimbra, Coimbra, Portugal[36]Faculty of Medicine, Coimbra Institute for Clinical and BiomedicalResearch (ICBR), University of Coimbra, Coimbra, Portugal[37]Faculty of Medicine, Institute of Immunology, University of Coimbra,Coimbra, Portugal[38]Department of Prevention of Environmental Hazards, Allergology andImmunology, Medical University of Warsaw, Warsaw, Poland[39]Finnish Meteorological Institute (FMI), Helsinki, Finland[40]Institute of Clinical Medicine and Institute of Health Sciences, MedicalFaculty of Vilnius University, Vilnius, Lithuania[41]Unit of Geriatric Immunoallergology, University of Bari Medical School,Bari, Italy[42]Institute of Sciences of Food Production, National Research Council (IspaCNR), Bari, Italy[43]Portuguese National Programme for Respiratory Diseases, Direção -Geralda Saúde, Faculdade de Medicina de Lisboa, Instituto de Saúde Ambiental,Lisbon, Portugal[44]University of Central Lancashire Medical School, Preston, UK[45]Department of Geriatrics, Montpellier University Hospital, MUSE,Montpellier, France[46]Department of Cardiovascular and Respiratory Sciences, UniversitaCattolica del Sacro Cuore, Rome, Italy[47]Department of Neurological, ENT and Thoracic Sciences, FondazionePoliclinico Universitario A Gemelli - IRCCS, Rome, Italy[48]Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec,Canada[49]University Hospital of Nice, Nice, France[50]Department of Respiratory Medicine, Ghent University Hospital, Ghent,Belgium[51]Department of Medical Sciences, University of Torino, Torino, Italy[52]Allergy and Clinical Immunology Unit, Mauriziano Hospital, Torino, Italy[53]Department of Pulmonary Medicine, Mainz University Hospital, Mainz,Germany[54]Allergy Section, Department of Internal Medicine, Hospital Vall d'Hebron,Barcelona, Spain[55]ARADyAL Research Network, Barcelona, Spain[56]Division of Allergy/Immunology, University of South Florida, Tampa,Florida, USA[57]SOS Allergology and Clinical Immunology, USL Toscana Centro, Prato, Italy[58]Clinique des Bronches, Allergie et Sommeil, Hôpital Nord, Marseille, France[59]Universidad Espíritu Santo, Samborondón, Ecuador[60]Respiralab Research Group, Guayas, Ecuador[61]ENT Department, Medical Faculty, Eskisehir Osmangazi University,Eskisehir, Turkey[62]UCIBIO, REQUINTE, Faculty of Pharmacy and Competence Center on Activeand Healthy Ageing, University of Porto (Porto4Ageing), Porto, Portugal[63]Fundaçao ProAR, Federal University of Bahia and GARD/WHO PlanningGroup, Salvador, Brazil[64]VIM Suresnes, UMR 0892, Pôle des Maladies des Voies Respiratoires,Hôpital Foch, Université Paris-Saclay, Suresnes, France[65]Department of Pediatric Pneumology, Immunology and Intensive CareMedicine, Charité Medical University, Berlin, Germany[66]Department of Otorhinolaryngology, Amsterdam University MedicalCentres, Amsterdam, The Netherlands[67]Center of Allergy and Immunology, David Tvildiani Medical University,Tbilisi, Georgia[68]Kazakhstan Association of Allergology and Clinical Immunology,Department of Allergology and Clinical Immunology of the Kazakh NationalMedical University, Almaty, Kazakhstan[69]Servicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires,Argentina[70]Poltava State Medical University, Poltava, Ukraine[71]Department of Otorhinolaryngology, Head and Neck Surgery, SemmelweisUniversity, Budapest, Hungary[72]Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest Diseasesand Allergology, Vilnius University, Vilnius, Lithuania[73]Department of Pathology, Faculty of Medicine, Institute of BiomedicalSciences, Vilnius University, Vilnius, Lithuania[74]Center of Excellence in Asthma and Allergy, Médica Sur ClinicalFoundation and Hospital, México City, Mexico[75]KYomed INNOV, Montpellier, France[76]Faculty of Health Sciences and CICS – UBI, Health Sciences ResearchCentre, University of Beira Interior, Covilhã, Portugal[77]Department of Pulmonary Medicine, CHU Liège, Liège, Belgium[78]GIGA I3 Research Group, University of Liège, Liège, Belgium[79]Allergy Unit "D Kalogeromitros," 2nd Department of Dermatology andVenereology, National & Kapodistrian University of Athens, "Attikon"University Hospital, Athens, Greece[80]Department of Clinical Science and Education, Södersjukhuset, KarolinskaInstitutet, Stockholm, Sweden[81]Sach's Children and Youth Hospital, Stockholm, Sweden[82]Allergy Center, CUF Descobertas Hospital, Lisbon, Portugal[83]Rhinology Unit & Smell Clinic, ENT Department, Hospital Clínic, Barcelona,Spain[84]Clinical & Experimental Respiratory Immunoallergy, IDIBAPS, CIBERES,University of Barcelona, Barcelona, Spain[85]Department of Allergology, Medical University of Gdansk, Gdansk, Poland[86]Allergy, Asthma and Clinical Immunology, Alfred Health and Departmentof Immunology, Central Clinical School, Monash University, Melbourne,Victoria, Australia[87]Chiba Rosai Hospital, Chiba, Japan[88]Chiba University Hospital, Chiba, Japan[89]Department of Otorhinolaryngology, Charité-Universitätsmedizin Berlin,Berlin, Germany[90]Berlin Institute of Health, Berlin, Germany[91]Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens,Greece[92]Respiratory Medicine, Department of Translational Medicine, University ofFerrara, Ferrara, Italy[93]Division of Allergy and Clinical Immunology, Department of Medicine,"Santa Maria della Speranza" Hospital, Battipaglia, Salerno, Italy[94]Agency of Health ASL, Salerno, Italy[95]Postgraduate Programme in Allergy and Clinical Immunology, University ofNaples Federico II, Naples, Italy[96]Department of Public Health, University of Liège, Liège, Belgium[97]Ecole Polytechnique de Palaiseau, Palaiseau, France[98]IRBA (Institut de Recherche Bio-Médicale des Armées), Brétigny sur Orge,France[99]Université Paris Cité, Paris, France[100]Personalized Medicine, Asthma & Allergy, Humanitas Clinical andResearch Center IRCCS, Rozzano, Milan, Italy[101]Department of Allergy, Hospital La Paz Institute for Health Research(IdiPAZ), Madrid, Spain[102]Pneumologie, AP-HP Centre Université de Paris Cité, Hôpital Cochin, etUMR 1016, Institut Cochin, Paris, France[103]Department of Otolaryngology, Head and Neck Surgery, Eye and Ear,University Hospital, Beirut, Lebanon[104]Department of Otolaryngology, Head and Neck Surgery, Dar Al ShifaHospital - Salmiya, Hawally, Kuwait[105]Department of Medicine, Division of Respiratory Medicine andAllergology, Showa University School of Medicine, Tokyo, Japan[106]Allergy Service, Fundacion Jimenez Diaz, Autonoma University of Madrid,CIBERES-ISCIII, Madrid, Spain[107]PROMISE Department, University of Palermo, Palermo, Italy[108]Usher Institute, The University of Edinburgh, Edinburgh, UK[109]Department of Respiratory Medicine and Tuberculosis, UniversityHospital Brno, Lískovec, Czech Republic[110]Department of Respiratory Medicine, Copenhagen University HospitalHvidovre, Copenhagen, Denmark[111]Institute of Clinical Medicine, University of Copenhagen, Copenhagen,Denmark[112]Department of Immunoallergology, Cova da Beira University HospitalCentre, Covilhã, Portugal[113]UBIAir - Clinical & Experimental Lung Centre and CICS-UBI HealthSciences Research Centre, University of Beira Interior, Covilhã, Portugal[114]Imunoalergologia, Faculty of Medicine, Centro Hospitalar Universitário deCoimbra, University of Coimbra, Coimbra, Portugal[115]Allergy Unit, Málaga Regional University Hospital-IBIMA, Málaga, Spain[116]International Primary Care Respiratory Group (IPCRG), Aberdeen, UK[117]Health Planning Unit, Department of Social Medicine, Faculty ofMedicine, University of Crete, Heraklion, Greece[118]Royal Brompton Hospital, Airways Disease Section, London, UK[119]Department of Lung Diseases and Clinical Immunology, University ofTurku, Turku, Finland[120]FIHLA, Finnish Lung Health Association, Helsinki, Finland[121]Department of Clinical Medicine, Pulmonary Diseases and ClinicalAllergology, University of Turku, Turku, Finland[122]Nova Southeastern University, College of Allopathic Medicine, FortLauderdale, Florida, USA[123]Department of Medicine, Clinical Immunology and Allergy, McMasterUniversity, Hamilton, Ontario, Canada[124]University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia[125]Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia[126]Department of Pulmonary Diseases, Faculty of Medicine, Celal BayarUniversity, Manisa, Turkey[127]Department of Otolaryngology Head and Neck Surgery, Beijing TongRenHospital and Beijing Institute of Otolaryngology, Beijing, China临床科室耳鼻咽喉-头颈外科研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[128]School of Medicine, University CEU San Pablo, Madrid, Spain[129]Department of Infection and Immunity, Luxembourg Institute of Health,Esch-sur-Alzette, Luxembourg[130]Department of Dermatology and Allergy Centre, Odense UniversityHospital, Odense Research Center for Anaphylaxis (ORCA), Odense,Denmark
Biomarkers for the diagnosis, treatment and follow-up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There are no validated biomarkers in rhinitis or allergen immunotherapy (AIT) that can be used in clinical practice. The digital transformation of health and health care (including mHealth) places the patient at the center of the health system and is likely to optimize the practice of allergy. Allergic Rhinitis and its Impact on Asthma (ARIA) and EAACI (European Academy of Allergy and Clinical Immunology) developed a Task Force aimed at proposing patient-reported outcome measures (PROMs) as digital biomarkers that can be easily used for different purposes in rhinitis and asthma. It first defined control digital biomarkers that should make a bridge between clinical practice, randomized controlled trials, observational real-life studies and allergen challenges. Using the MASK-air app as a model, a daily electronic combined symptom-medication score for allergic diseases (CSMS) or for asthma (e-DASTHMA), combined with a monthly control questionnaire, was embedded in a strategy similar to the diabetes approach for disease control. To mimic real-life, it secondly proposed quality-of-life digital biomarkers including daily EQ-5D visual analogue scales and the bi-weekly RhinAsthma Patient Perspective (RAAP). The potential implications for the management of allergic respiratory diseases were proposed.
基金：
Charité
Universitätsmedizin Berlin, EU grants (EU Structural and Development Funds Languedoc
Roussillon and Region PACA; POLLAR: EIT Health; Twinning: EIP on AHA; Twinning
DHE: H2020; Catalyse: Horizon Europe) and educational grants from Mylan-Viatris, ALK,
GSK, Novartis, Stallergènes-Greer and Uriach.
第一作者机构：[1]Institute of Allergology, Charité – Universitätsmedizin Berlin, FreieUniversität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany[2]University Hospital Montpellier, Montpellier, France[3]Fraunhofer Institute for Translational Medicine and Pharmacology ITMP,Allergology and Immunology, Berlin, Germany[*1]Institute of Allergology,Charité – Universitätsmedizin Berlin, Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany.
通讯作者：
通讯机构：[1]Institute of Allergology, Charité – Universitätsmedizin Berlin, FreieUniversität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany[2]University Hospital Montpellier, Montpellier, France[3]Fraunhofer Institute for Translational Medicine and Pharmacology ITMP,Allergology and Immunology, Berlin, Germany[*1]Institute of Allergology,Charité – Universitätsmedizin Berlin, Freie Universität Berlin and HumboldtUniversität zu Berlin, Berlin, Germany.
推荐引用方式(GB/T 7714)：
Jean Bousquet,Mohamed H. Shamji,Josep M. Anto,et al.Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report[J].ALLERGY.2023,78(7):1758-1776.doi:10.1111/all.15740.
APA：
Jean Bousquet,Mohamed H. Shamji,Josep M. Anto,Holger J. Schünemann,G. Walter Canonica...&Markus Ollert.(2023).Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report.ALLERGY,78,(7)
MLA：
Jean Bousquet,et al."Patient-centered digital biomarkers for allergic respiratory diseases and asthma: The ARIA-EAACI approach - ARIA-EAACI Task Force Report".ALLERGY 78..7(2023):1758-1776
医学