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Treating amblyopia using altered reality enhances the fine-scale functional correlations in early visual areas

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机构: [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [3]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China [4]State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China [5]School of Psychology, Shenzhen University, Shenzhen, Guangdong, China [6]Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, US
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关键词: adaptation altered reality amblyopia functional connectivity plasticity

摘要:
Amblyopia is a developmental visual disorder that causes substantial visual deficits. Studies using resting-state functional magnetic resonance imaging have disclosed abnormal brain functional connectivity (FC) both across long-range cortical sites and within the visual cortex in amblyopes, which is considered to be related to impaired visual functions. However, little work has examined whether restoring the vision of amblyopes accompanies with an improvement of FC. Here in adult amblyopes and healthy participants, we compared their brain FC before and after an altered-reality adaptation training. Before the training, the voxel-wise FCs of amblyopia patients were substantially weaker than those of healthy control participants both within and across the early visual areas. After the training, visual acuities improved in amblyopes but not in the control participants. The effect kept strengthening in the subsequent month without further adaptation. Importantly, we observed enhanced voxel-wise FC both within and across the early visual areas of amblyopes. Moreover, the enhancement continued for at least 1 month. These results suggest that the effective treatment can improve both the amblyopes' vision and functional connections in the visual cortex.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 神经成像 2 区 神经科学 2 区 核医学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 神经成像 2 区 核医学 3 区 神经科学
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出版当年[2021]版:
Q1 NEUROIMAGING Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 NEUROSCIENCES
最新[2024]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 NEUROIMAGING Q2 NEUROSCIENCES

影响因子: 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
通讯作者:
通讯机构: [1]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China [2]Department of Psychology, University of Chinese Academy of Sciences, Beijing, China [5]School of Psychology, Shenzhen University, Shenzhen, Guangdong, China [6]Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, US [*1]Department of Psychiatry and Behavioral Sciences, Emory University, 201 Dowman Drive, Atlanta, Georgia 30322, USA. [*2]CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China
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